Document Detail


Biological monitoring of experimental human exposure to hydrocarbon solvent mixtures.
MedLine Citation:
PMID:  16269218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to develop and to validate a suitable analytical method in order to assess the internal exposure of persons to commercial products of hydrocarbon solvent mixtures (HSM). Twenty healthy volunteers were exposed to vapours of five commercial HSM for 8h at 200-1,000 mg/m(3) air. Aromatic-rich, aromatic-poor and aromatic-free HSM were used, as well as isohexane and technical hexane mixtures. A total of 300 exposures were carried out at rest or with an exercise period of 10 min/h at 50 and 75 W. Blood samples for the determination of the HSM were collected before and immediately after exposure. They were analyzed with a headspace analyzer by gas chromatography and mass spectrometry. The analytical method has detection limits of 2-50 microg HSM/L blood. With this method we obtained intra- and interassay variation coefficients of 3.7-15.1%, at concentrations of 53-1,500 microg HSM/L blood. The mean values of the HSM of the 20 volunteers after 8h range between 89 mug/L (technical hexane-mixture) and 1,369 microg/L blood (aromatic-free HSM) at rest. Physical exercises of 50 and 75 W, respectively, lead to a significant increase of the blood-concentrations by mean factors between 1.2 and 1.9 for the five HSM. In conclusion, our results demonstrate that physical activity should be considered in the setting of occupational exposure limits.
Authors:
Holger Zimmer; Holger Uhlich; Udo Knecht; Gerhard Triebig
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-02
Journal Detail:
Title:  Toxicology letters     Volume:  162     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-02-20     Completed Date:  2006-04-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  263-9     Citation Subset:  IM    
Affiliation:
Institute and Outpatient Clinic of Occupational and Social Medicine, University Hospital of Heidelberg, Hospitalstrasse 1, D-69115 Heidelberg, Germany. holger.zimmer@med.uni-heidelberg.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Air Pollutants, Occupational / blood*
Environmental Monitoring / methods
Exercise
Female
Humans
Hydrocarbons / blood*
Inhalation Exposure / analysis
Male
Middle Aged
Occupational Exposure / analysis
Reproducibility of Results
Solvents / metabolism*
Threshold Limit Values
Chemical
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Hydrocarbons; 0/Solvents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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