Document Detail


Biological markers and therapeutic outcome in alcoholic disease: a twelve-year survey.
MedLine Citation:
PMID:  3560786     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The early diagnosis and evaluation of the biological consequences of alcohol abuse are reviewed in a population of 401 chronic alcoholics admitted to our Toxicological Unit from January 1973 to the end of December 1984; selected cases were treated with disulfiram implantation. The results of the study indicate that anemia with increased globular volume of erythrocytes, elevated serum gamma-glutamyl-transferase activity, increased postprandial cholalemia, and increased elimination of pentane in the breath can be considered suitable markers for the early diagnosis of alcohol abuse. Disulfiram implantation significantly prolonged the abstinence duration in the treated patients.
Authors:
R Fantozzi; L Caramelli; F Ledda; F Moroni; E Masini; P Blandina; P Botti; S Peruzzi; A M Zorn; P F Mannaioni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Klinische Wochenschrift     Volume:  65     ISSN:  0023-2173     ISO Abbreviation:  Klin. Wochenschr.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-04-27     Completed Date:  1987-04-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985205R     Medline TA:  Klin Wochenschr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  27-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Dehydrogenase / blood*
Alcoholism / enzymology,  rehabilitation*
Aldehyde Dehydrogenase / blood*
Disulfiram / therapeutic use
Drug Implants
Female
Follow-Up Studies
Humans
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Drug Implants; 97-77-8/Disulfiram; EC 1.1.1.1/Alcohol Dehydrogenase; EC 1.2.1.3/Aldehyde Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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