| Biological markers of exposure to SO2: S-sulfonates in nasal lavage. | |
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MedLine Citation:
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PMID: 8173339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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S-sulfonate levels were measured in the nasal lavage (NAL) fluid of humans exposed to sulfur dioxide as a potential biological marker of exposure. These levels were determined by treating NAL fluid protein with cyanide to cleave the S-S linkage and release the sulfite. The cyanolytically released sulfite was measured by ion chromatography. In two experiments, humans were exposed to air or 1 ppm SO2 for 10 minute, and to air or 7 ppm SO2 for 20 minutes and lavaged immediately after exposure. Releasable sulfite levels in NAL fluid were 1.06 +/- 0.24 and 2.61 +/- 0.55 micrograms SO=3/mg protein, respectively (mean +/- SE, n = 5), for the first experiment, and 1.16 +/- 0.37 and 4.91 +/- 0.76 micrograms SO=3/mg protein, respectively (mean +/- SE, n = 8), for the second. The subjects in the former study were persons with asthma. In both experiments, S-sulfonate levels were statistically elevated in the exposed group compared with the control groups (p < 0.05, paired t-test). The same individuals in the second experiment received five additional 20-minute exposures to 7 ppm SO2 every other day, for a total of six exposures. NAL fluid taken at the conclusion of the final exposure had releasable sulfite levels of 4.99 +/- 1.36 micrograms SO=3/mg protein; these levels were statistically elevated relative to controls but were not elevated relative to the 1-day exposure (mean +/- SE, n = 8). The lack of accumulation of S-sulfonates after 6 days of short-term exposure suggests clearance of these compounds from the nasal passages within 24 hours. The levels of S-sulfonates observed in NAL fluid in this study are almost three orders of magnitude higher than those measured in plasma following similar SO2 exposures. Measurement of S-sulfonates in the nasal passage may be an effective short-term biomarker of exposure to SO2. |
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Authors:
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W E Bechtold; J J Waide; T Sandström; N Stjernberg; D McBride; J Koenig; I Y Chang; R F Henderson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of exposure analysis and environmental epidemiology Volume: 3 ISSN: 1053-4245 ISO Abbreviation: J Expo Anal Environ Epidemiol Publication Date: 1993 Oct-Dec |
Date Detail:
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Created Date: 1994-06-06 Completed Date: 1994-06-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9111438 Medline TA: J Expo Anal Environ Epidemiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 371-82 Citation Subset: IM |
Affiliation:
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Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Environmental Exposure* Female Humans Male Nasal Lavage Fluid / chemistry* Sulfonic Acids / analysis* Sulfur Dioxide / pharmacokinetics* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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ES04282/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sulfonic Acids; 7446-09-5/Sulfur Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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