| Biological lung volume reduction: a new bronchoscopic therapy for advanced emphysema. | |
| | |
MedLine Citation:
|
PMID: 17426216 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Biological lung volume reduction (BLVR) using biological reagents to remodel and shrink damaged regions of lung has previously been accomplished in sheep with experimental pulmonary emphysema. This report summarizes the initial clinical experience including a 3-month follow-up using this technique in humans. METHODS: An open-label phase 1 trial designed to evaluate the safety of BLVR in patients with advanced heterogeneous emphysema enrolled six patients. Of these, three patients received unilateral treatment at two pulmonary subsegments (group 1) and three patients received unilateral treatment at four pulmonary subsegments (group 2). The incidence of adverse events and changes in pulmonary function test results, symptoms, and exercise capacity were evaluated. RESULTS: The mean (+/- SD) age of the six men enrolled in the study was 66 +/- 5.7 years (age range, 57 to 73 years). BLVR was well tolerated in both treatment groups and was not associated with any serious complications. All patients were discharged from the hospital on posttreatment day 1. Although the primary purpose of the study was to examine safety, improvements were observed in mean vital capacity (+7.2 +/- 9.5%; range, -2% to + 19%), mean residual volume (RV) [-7.8 +/- 8.5%; range, + 1% to -22%], mean RV/total lung capacity ratio (-6.6 +/- 4.7%; range, -1% to -15%), mean 6-min walk distance (+14.5 +/- 18.5%; range, 0 to + 51%), and in mean dyspnea score. On average, group 2 patients experienced greater benefit from BLVR than group 1 patients, suggesting a dose-response pattern. CONCLUSIONS: Preliminary results indicate that BLVR can be safe and may produce benefits in appropriately selected patients with advanced heterogeneous emphysema. |
| | |
Authors:
|
John Reilly; George Washko; Victor Pinto-Plata; Eduardo Velez; Lawrence Kenney; Robert Berger; Bartolome Celli |
Related Documents
:
|
15181326 - Time course from first symptom to the treatment of lung cancer in the eastern black sea... 13905846 - Aggressive treatment of spontaneous pneumothorax. 19159726 - Thoracoscopic decortication vs tube thoracostomy with fibrinolysis for empyema in child... 17587416 - Preoperative maximal exercise oxygen consumption test predicts postoperative pulmonary ... 19662486 - Comparison of the effects of short- and long-pulse durations when using a 585-nm pulsed... 22182386 - Narrowband ultraviolet b (311 nm, tl01) phototherapy in chronic ordinary urticaria. |
Publication Detail:
|
Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Chest Volume: 131 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2007 Apr |
Date Detail:
|
Created Date: 2007-04-11 Completed Date: 2007-05-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
|
Languages: eng Pagination: 1108-13 Citation Subset: AIM; IM |
Affiliation:
|
Brigham and Women's Hospital, Pulmonary/Critical Care Medicine, 75 Francis St, Boston, MA 02115-6110, USA. jreilly@partners.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Bronchoscopy* Female Follow-Up Studies Humans Male Middle Aged Pneumonectomy / methods* Pulmonary Emphysema / physiopathology, radiography, surgery* Residual Volume Severity of Illness Index Time Factors Tomography, X-Ray Computed Treatment Outcome Vital Capacity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Predictors of decreased spontaneous baroreflex sensitivity in obstructive sleep apnea syndrome.
Next Document: Tracheobronchial laceration after balloon dilation for benign strictures: incidence and clinical sig...