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Biological importance and applications of squalene and squalane.
MedLine Citation:
PMID:  22361190     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Squalene is a polyunsaturated hydrocarbon with a formula of C(30)H(50). Squalene can be found in certain fish oils, especially shark liver oil, in high amounts and some vegetable oils in relatively smaller amounts. Human sebum also contains 13% squalene as one of its major constituents. Squalane is a saturated derivative of squalene and also found in these sources. Interest in squalene has been raised after its characterization in shark liver oil which is used as a traditional medicine for decades. Several studies exhibited results that prove certain bioactivities for squalene and squalane. Up to date, anticancer, antioxidant, drug carrier, detoxifier, skin hydrating, and emollient activities of these substances have been reported both in animal models and in vitro environments. According to promising results from recent studies, squalene and squalane are considered important substances in practical and clinical uses with a huge potential in nutraceutical and pharmaceutical industries.
Authors:
Se-Kwon Kim; Fatih Karadeniz
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in food and nutrition research     Volume:  65     ISSN:  1043-4526     ISO Abbreviation:  Adv. Food Nutr. Res.     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001271     Medline TA:  Adv Food Nutr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Chemistry, Pukyong National University, Busan, Republic of Korea; Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea.
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