| Biological implications of oxidation and unidirectional chiral inversion of D-amino acids. | |
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MedLine Citation:
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PMID: 22304623 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Recent progress in chiral separation of D- and L-amino acids by chromatography ascertained the presence of several free D-amino acids in a variety of mammals including humans. Unidirectional chiral inversion of many D-amino acid analogs such as exogenous NG-nitro-D-arginine (D-NNA), endogenous D-leucine, D-phenylanine and D-methionine have been shown to take place with inversion rates of 4-90%, probably dependent on various species D-amino acid oxidase (DAAO) enzymatic activities. DAAO is known to catalyze the oxidative deamination of neutral and basic D-amino acids to their corresponding α-keto acids, hydrogen peroxide and ammonia, and is responsible for the chiral inversion. This review provides an overview of recent research in this area: 1) oxidation and chiral inversion of several D-amino acid analogs in the body; 2) the indispensable but insufficient role of DAAO particularly in the kidneys and brain for the oxidation and chiral inversion of D-amino acids analogs; and 3) unidentified transaminase(s) responsible for the second step of chiral inversion. The review also discusses the physiological significance of oxidation and chiral inversion of D-amino acids, which is still a subject of dispute. |
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Authors:
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Yong-Xiang Wang; Nian Gong; Yan-Fei Xin; Bin Hao; Xiang-Jun Zhou; Catherine C Y Pang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-2 |
Journal Detail:
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Title: Current drug metabolism Volume: - ISSN: 1875-5453 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100960533 Medline TA: Curr Drug Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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King's Lab, School of Pharmacy, Shanghai Jiao Tong University, NO. 6 Biomedicine Building (Suite 106), 800 Dongchuan Road, Shanghai 200240, China. yxwang@sjtu.edu.cn. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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