Document Detail

Biological implications of cell fusion.
MedLine Citation:
PMID:  15957005     Owner:  NLM     Status:  MEDLINE    
Until recently, cells were thought to be integral and discrete components of tissues, and their state was determined by cell differentiation. However, under some conditions, stem cells or their progeny can fuse with cells of other types, mixing cytoplasmic and even genetic material of different (heterotypic) origins. The fusion of heterotypic cells could be of central importance for development, repair of tissues and the pathogenesis of disease.
Brenda M Ogle; Marilia Cascalho; Jeffrey L Platt
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Nature reviews. Molecular cell biology     Volume:  6     ISSN:  1471-0072     ISO Abbreviation:  Nat. Rev. Mol. Cell Biol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-08-02     Completed Date:  2005-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100962782     Medline TA:  Nat Rev Mol Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  567-75     Citation Subset:  IM    
Transplantation Biology and the Department of Physiology, Mayo Clinic, Rochester, Minnesota 55905, USA.
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MeSH Terms
Aging / physiology
Cell Differentiation
Cell Fusion*
Models, Biological
Stem Cells / cytology,  physiology*

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