Document Detail

Biological half-lives of zinc and manganese in rat brain.
MedLine Citation:
PMID:  8574647     Owner:  NLM     Status:  MEDLINE    
The brains of rats injected intravenously with 65ZnCl2 or 54MnCl2 were subjected to high-resolution autoradiography. The distribution of 65Zn and 54Mn in each brain region gradually decreased from 6 days to 42 days for 65Zn and from 15 days to 60 days for 54Mn after the injection. The biological half-lives of Zn in each region studied were in the range of 16-43 days; the longest was observed in the amygdaloid nuclei. The regions where the long biological half-life was observed were consistent with the ones with the high density of Zn-containing neuron terminals reported previously. The biological half-lives of Mn in each region were 51-74 days; the longest were those in the hypothalamic nuclei and thalamus.
A Takeda; J Sawashita; S Okada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  695     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-03-12     Completed Date:  1996-03-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  53-8     Citation Subset:  IM    
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
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MeSH Terms
Brain / metabolism*
Cerebral Cortex / metabolism
Manganese / metabolism*
Radioligand Assay
Rats, Wistar
Time Factors
Tissue Distribution
Zinc / metabolism*
Reg. No./Substance:
7439-96-5/Manganese; 7440-66-6/Zinc

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