| Biological half-lives of zinc and manganese in rat brain. | |
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MedLine Citation:
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PMID: 8574647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The brains of rats injected intravenously with 65ZnCl2 or 54MnCl2 were subjected to high-resolution autoradiography. The distribution of 65Zn and 54Mn in each brain region gradually decreased from 6 days to 42 days for 65Zn and from 15 days to 60 days for 54Mn after the injection. The biological half-lives of Zn in each region studied were in the range of 16-43 days; the longest was observed in the amygdaloid nuclei. The regions where the long biological half-life was observed were consistent with the ones with the high density of Zn-containing neuron terminals reported previously. The biological half-lives of Mn in each region were 51-74 days; the longest were those in the hypothalamic nuclei and thalamus. |
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Authors:
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A Takeda; J Sawashita; S Okada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain research Volume: 695 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1996-03-12 Completed Date: 1996-03-12 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 53-8 Citation Subset: IM |
Affiliation:
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Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoradiography Brain / metabolism* Cerebral Cortex / metabolism Male Manganese / metabolism* Radioligand Assay Rats Rats, Wistar Time Factors Tissue Distribution Zinc / metabolism* |
| Chemical | |
Reg. No./Substance:
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7439-96-5/Manganese; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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