| Biological functions and transcriptional targets of CaRF in neurons. | |
| | |
MedLine Citation:
|
PMID: 21565403 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Calcium-response factor (CaRF) is a unique DNA-binding protein first recognized as a transcription factor for its role in modulating transcription of the gene encoding Brain-Derived Neurotrophic Factor (BDNF) in neurons. Here I review evidence for the biological functions and transcriptional targets of CaRF in the brain and discuss potential mechanisms by which calcium-activated signaling pathways may modulate CaRF-dependent transcription. These data paint an emerging picture of CaRF as a regulatory nexus for signaling pathways that control aspects of synaptic development and neuronal function. |
| | |
Authors:
|
Anne E West |
Related Documents
:
|
17672643 - A mechano-acoustic model of the effect of superior canal dehiscence on hearing in chinc... 12543153 - Central tinnitus. 16435363 - Gap-43 heterozygous mice show delayed barrel patterning, differentiation of radial glia... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-05-11 |
Journal Detail:
|
Title: Cell calcium Volume: 49 ISSN: 1532-1991 ISO Abbreviation: Cell Calcium Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-06-13 Completed Date: 2011-09-28 Revised Date: 2012-05-16 |
Medline Journal Info:
|
Nlm Unique ID: 8006226 Medline TA: Cell Calcium Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 290-5 Citation Subset: IM |
Copyright Information:
|
2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, NC 27710, USA. west@neuro.duke.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain-Derived Neurotrophic Factor / genetics, metabolism Calcium Signaling Mice Neurons / metabolism* Transcription Factors / metabolism, physiology* Transcription, Genetic |
| Grant Support | |
ID/Acronym/Agency:
|
1-R01-DA022202/DA/NIDA NIH HHS; R01 DA022202-05/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Brain-Derived Neurotrophic Factor; 0/Carf protein, mouse; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The risk of intra-amniotic infection, inflammation and histologic chorioamnionitis in term pregnant ...
Next Document: Increased MLL gene rearrangements in amniocytes from fetuses of mothers who smoke.