Document Detail

Biological functions and transcriptional targets of CaRF in neurons.
MedLine Citation:
PMID:  21565403     Owner:  NLM     Status:  MEDLINE    
Calcium-response factor (CaRF) is a unique DNA-binding protein first recognized as a transcription factor for its role in modulating transcription of the gene encoding Brain-Derived Neurotrophic Factor (BDNF) in neurons. Here I review evidence for the biological functions and transcriptional targets of CaRF in the brain and discuss potential mechanisms by which calcium-activated signaling pathways may modulate CaRF-dependent transcription. These data paint an emerging picture of CaRF as a regulatory nexus for signaling pathways that control aspects of synaptic development and neuronal function.
Anne E West
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-05-11
Journal Detail:
Title:  Cell calcium     Volume:  49     ISSN:  1532-1991     ISO Abbreviation:  Cell Calcium     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-06-13     Completed Date:  2011-09-28     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8006226     Medline TA:  Cell Calcium     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  290-5     Citation Subset:  IM    
Copyright Information:
2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Brain-Derived Neurotrophic Factor / genetics,  metabolism
Calcium Signaling
Neurons / metabolism*
Transcription Factors / metabolism,  physiology*
Transcription, Genetic
Grant Support
1-R01-DA022202/DA/NIDA NIH HHS; R01 DA022202/DA/NIDA NIH HHS; R01 DA022202-05/DA/NIDA NIH HHS
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/Carf protein, mouse; 0/Transcription Factors

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