| Biological functions of SLC5A8, a candidate tumour suppressor. | |
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MedLine Citation:
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PMID: 15667316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SLC5A8 is a candidate tumour suppressor gene that is silenced in colon cancer, gastric cancer and possibly other cancers in humans. This gene codes for a transporter belonging to the Na(+)/glucose co-transporter gene family (SLC5). The cancer-associated silencing of the gene involves hypermethylation of CpG islands present in exon 1 of the gene. SLC5A8 is expressed in colon, ileum, kidney and thyroid gland. The protein coded by the gene mediates the Na(+)-coupled and electrogenic transport of a variety of monocarboxylates, including short-chain fatty acids, lactate and nicotinate. It may also transport iodide. The normal physiological function of this transporter in the intestinal tract and kidney is likely to facilitate the active absorption of short-chain fatty acids, lactate and nicotinate. One of the short-chain fatty acids that serves as a substrate for SLC5A8 is butyrate. This fatty acid is an inhibitor of histone deacetylases and is known to induce apoptosis in a variety of tumours including colonic tumour. Since butyrate is produced in the colonic lumen at high concentrations by bacterial fermentation of dietary fibre, we speculate that the ability of SLC5A8 to mediate the entry of this short-chain fatty acid into colonic epithelial cells underlies the potential tumour suppressor function of this transporter. |
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Authors:
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V Ganapathy; E Gopal; S Miyauchi; P D Prasad |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biochemical Society transactions Volume: 33 ISSN: 0300-5127 ISO Abbreviation: Biochem. Soc. Trans. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-25 Completed Date: 2005-07-05 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7506897 Medline TA: Biochem Soc Trans Country: England |
Other Details:
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Languages: eng Pagination: 237-40 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA. vganapat@mail.mcg.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cation Transport Proteins
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genetics,
physiology* Gene Silencing Genes, Tumor Suppressor* Humans |
| Chemical | |
Reg. No./Substance:
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0/Cation Transport Proteins; 0/SLC5A8 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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