| Biological exposure indicators: quantification of biological variability using toxicokinetic modeling. | |
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MedLine Citation:
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PMID: 16464817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Compartmental and physiologically based toxicokinetic modeling coupled with Monte Carlo simulation were used to quantify the impact of biological variability (physiological, biochemical, and anatomic parameters) on the values of a series of bio-indicators of metal and organic industrial chemical exposures. A variability extent index and the main parameters affecting biological indicators were identified. Results show a large diversity in interindividual variability for the different categories of biological indicators examined. Measurement of the unchanged substance in blood, alveolar air, or urine is much less variable than the measurement of metabolites, both in blood and urine. In most cases, the alveolar flow and cardiac output were identified as the prime parameters determining biological variability, thus suggesting the importance of workload intensity on absorbed dose for inhaled chemicals. |
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Authors:
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Ginette Truchon; Robert Tardif; Pierre-Olivier Droz; Ginette Charest-Tardif; Guillaume Pierrehumbert |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of occupational and environmental hygiene Volume: 3 ISSN: 1545-9624 ISO Abbreviation: J Occup Environ Hyg Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-08 Completed Date: 2006-07-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101189458 Medline TA: J Occup Environ Hyg Country: United States |
Other Details:
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Languages: eng Pagination: 137-43 Citation Subset: IM |
Affiliation:
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Institut de recherche Robert-Sauvé en santé et en sécurité du travail, Montréal, Québec, Canada. truchon.ginette@irsst.qc.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Air Pollutants, Occupational
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pharmacokinetics* Environmental Monitoring / methods* Humans Metals, Heavy / pharmacokinetics Models, Biological* Monte Carlo Method Occupational Exposure / analysis* Organic Chemicals / pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants, Occupational; 0/Metals, Heavy; 0/Organic Chemicals |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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