Document Detail


Biological evaluation of 99mTc labelled cis-platinum containing benzyliminodiacetic acids as potential tumour imaging agents.
MedLine Citation:
PMID:  2143755     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The synthesis of three new potential tumour-imaging radiopharmaceuticals in which a cis-platin derivative is attached to benzyl iminodiacetic acid, a ligand capable of forming a stable complex with 99mTc, has previously been reported by us [Awaluddin et al. Appl. Radiat. Isot. 38, 671-674 (1987)]. We have now carried out extensive biodistribution studies on these compounds as well as on two fragments of their structures which do not contain platinum. The results suggest that the presence of platinum is not essential for the tumour-localizing properties of the radiopharmaceuticals.
Authors:
J J Jacobs; D J Maddalena; J G Wilson; A Awaluddin; J King-Christopher; D W Bourne
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology     Volume:  17     ISSN:  0883-2897     ISO Abbreviation:  Int J Rad Appl Instrum B     Publication Date:  1990  
Date Detail:
Created Date:  1990-09-27     Completed Date:  1990-09-27     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  8611098     Medline TA:  Int J Rad Appl Instrum B     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  397-400     Citation Subset:  IM    
Affiliation:
Pharmacy Department, University of Queensland, St Lucia, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cisplatin / analogs & derivatives*,  diagnostic use,  pharmacokinetics*
Imino Acids / diagnostic use,  pharmacokinetics
Mice
Mice, Inbred BALB C
Neoplasm Transplantation
Sarcoma, Experimental / metabolism*
Specific Pathogen-Free Organisms
Tissue Distribution
Chemical
Reg. No./Substance:
0/Imino Acids; 15663-27-1/Cisplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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