| Biological evaluation of 99mTc labelled cis-platinum containing benzyliminodiacetic acids as potential tumour imaging agents. | |
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MedLine Citation:
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PMID: 2143755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The synthesis of three new potential tumour-imaging radiopharmaceuticals in which a cis-platin derivative is attached to benzyl iminodiacetic acid, a ligand capable of forming a stable complex with 99mTc, has previously been reported by us [Awaluddin et al. Appl. Radiat. Isot. 38, 671-674 (1987)]. We have now carried out extensive biodistribution studies on these compounds as well as on two fragments of their structures which do not contain platinum. The results suggest that the presence of platinum is not essential for the tumour-localizing properties of the radiopharmaceuticals. |
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Authors:
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J J Jacobs; D J Maddalena; J G Wilson; A Awaluddin; J King-Christopher; D W Bourne |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Volume: 17 ISSN: 0883-2897 ISO Abbreviation: Int J Rad Appl Instrum B Publication Date: 1990 |
Date Detail:
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Created Date: 1990-09-27 Completed Date: 1990-09-27 Revised Date: 2008-02-21 |
Medline Journal Info:
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Nlm Unique ID: 8611098 Medline TA: Int J Rad Appl Instrum B Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 397-400 Citation Subset: IM |
Affiliation:
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Pharmacy Department, University of Queensland, St Lucia, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cisplatin / analogs & derivatives*, diagnostic use, pharmacokinetics* Imino Acids / diagnostic use, pharmacokinetics Mice Mice, Inbred BALB C Neoplasm Transplantation Sarcoma, Experimental / metabolism* Specific Pathogen-Free Organisms Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Imino Acids; 15663-27-1/Cisplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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