Document Detail

Biological effects of two successive shock waves focused on liver tissues and melanoma cells.
MedLine Citation:
PMID:  17552901     Owner:  NLM     Status:  MEDLINE    
A new generator of two successive shock waves focused to a common focal point has been developed. Cylindrical pressure waves created by multichannel electrical discharges on two cylindrical composite anodes are focused by a metallic parabolic reflector - cathode, and near the focus they are transformed to strong shock waves. Schlieren photos of the focal region have demonstrated that mutual interaction of the two waves results in generation of a large number of secondary short-wavelength shocks. Interaction of the focused shockwaves with liver tissues and cancer cell suspensions was investigated. Localized injury of rabbit liver induced by the shock waves was demonstrated by magnetic resonance imaging. Histological analysis of liver samples taken from the injured region revealed that the transition between the injured and the healthy tissues is sharp. Suspension of melanoma B16 cells was exposed and the number of the surviving cells rapidly decreased with increasing number of shocks and only 8 % of cells survived 350 shocks. Photographs of cells demonstrate that even small number of shocks results in perforation of cell membranes.
J Benes; P Sunka; J Králová; J Kaspar; P Poucková
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-31
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  56 Suppl 1     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2007  
Date Detail:
Created Date:  2008-01-16     Completed Date:  2008-04-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  S1-4     Citation Subset:  IM    
First Medical Faculty, Charles University, Prague, Czech Republic.
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MeSH Terms
Cell Line, Tumor
Cell Membrane / pathology*
Cell Survival / radiation effects
Equipment Design
Liver / injuries,  pathology*
Magnetic Resonance Imaging
Melanoma, Experimental / pathology*
Mice, Inbred C57BL
Time Factors
Ultrasonics / adverse effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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