Document Detail


Biological effects of a S/D-treated, very high purity, von Willebrand factor concentrate in five patients with severe von Willebrand disease.
MedLine Citation:
PMID:  8148475     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A highly purified von Willebrand factor (vWf) concentrate with low factor VIII (FVIII) content was tested to evaluate its biological effects in five patients with severe von Willebrand disease (vWd). The patients were infused with a single dose of this product corresponding to approximately 65 IU vWf:RCo and approximately 11 IU FVIII:C/kg and were followed up for 48 h. The plasma levels of FVIII and vWf and the multimeric pattern of vWf were determined before and 1, 3, 6, 12, 24 and 48 h after infusion. In all patients the recovery (93 +/- 14%) and half-life (13 +/- 1 h) of vWf were consistent and normal and sustained FVIII levels were attained. In four patients both the duration and the volume of shed blood were measured after one incision with a standardized template method of bleeding time (BT). The duration of bleeding was completely corrected in two out of the four patients and partially corrected in the other two while the volume of shed blood was completely corrected in three patients and partially corrected in the fourth. However, the time for correction of both BT parameters was variable between patients. These data indicate that the vWf concentrate can correct the quantitative defects related to plasma vWf deficiency in vWd patients whereas the effect on template BT is less reproducible.
Authors:
F Meriane; L Zerhouni; N Djeha; M Goudemand; C Mazurier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  4     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-05-10     Completed Date:  1994-05-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1023-9     Citation Subset:  IM    
Affiliation:
Centre de Transfusion de Bab El Oued, Algiers, Algeria.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bleeding Time
Child
Child, Preschool
Factor VIII / analysis
Female
Humans
Male
von Willebrand Diseases / drug therapy*
von Willebrand Factor / isolation & purification,  therapeutic use*
Chemical
Reg. No./Substance:
0/von Willebrand Factor; 9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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