| Biological effects of noble gases. | |
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MedLine Citation:
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PMID: 17552896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Noble gases are known for their inertness. They do not react chemically with any element at normal temperature and pressure. Through that, some of them are known to be biologically active by their sedative, hypnotic and analgesic properties. Common inhalation anesthetics are characterized by some disadvantages (toxicity, decreased cardiac output, etc). Inhalation of xenon introduces anesthesia and has none of the above disadvantages, hence xenon seems to be the anesthetic gas of the future (with just one disadvantage - its cost). It is known that argon has similar anesthetic properties (under hyperbaric conditions), which is much cheaper and easily accessible. The question is if this could be used in clinical practice, in anesthesia of patients who undergo treatment in the hyperbaric chamber. Xenon was found to be organ-protective. Recent animal experiments indicated that xenon decreases infarction size after ischemic attack on brain or heart. The goal of our study is to check if hyperbaric argon has properties similar to those of xenon. |
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Authors:
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J Růzicka; J Benes; L Bolek; V Markvartová |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-05-31 |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 56 Suppl 1 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 2007 |
Date Detail:
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Created Date: 2008-01-16 Completed Date: 2008-04-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: Czech Republic |
Other Details:
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Languages: eng Pagination: S39-44 Citation Subset: IM |
Affiliation:
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Department of Biophysics, Faculty of Medicine, Charles University, Plzen, Czech Republic. benes@dante.lfp.cuni.cz |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Inhalation
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pharmacology* Animals Argon / pharmacology* Behavior, Animal / drug effects* Dose-Response Relationship, Drug Female Male Motor Activity / drug effects* Motor Skills / drug effects* Noble Gases / pharmacology* Pressure Rats Sleep / drug effects* Time Factors Wakefulness / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Noble Gases; 7440-37-1/Argon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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