Document Detail


Biological effects of noble gases.
MedLine Citation:
PMID:  17552896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Noble gases are known for their inertness. They do not react chemically with any element at normal temperature and pressure. Through that, some of them are known to be biologically active by their sedative, hypnotic and analgesic properties. Common inhalation anesthetics are characterized by some disadvantages (toxicity, decreased cardiac output, etc). Inhalation of xenon introduces anesthesia and has none of the above disadvantages, hence xenon seems to be the anesthetic gas of the future (with just one disadvantage - its cost). It is known that argon has similar anesthetic properties (under hyperbaric conditions), which is much cheaper and easily accessible. The question is if this could be used in clinical practice, in anesthesia of patients who undergo treatment in the hyperbaric chamber. Xenon was found to be organ-protective. Recent animal experiments indicated that xenon decreases infarction size after ischemic attack on brain or heart. The goal of our study is to check if hyperbaric argon has properties similar to those of xenon.
Authors:
J Růzicka; J Benes; L Bolek; V Markvartová
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-31
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  56 Suppl 1     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2007  
Date Detail:
Created Date:  2008-01-16     Completed Date:  2008-04-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  S39-44     Citation Subset:  IM    
Affiliation:
Department of Biophysics, Faculty of Medicine, Charles University, Plzen, Czech Republic. benes@dante.lfp.cuni.cz
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MeSH Terms
Descriptor/Qualifier:
Anesthetics, Inhalation / pharmacology*
Animals
Argon / pharmacology*
Behavior, Animal / drug effects*
Dose-Response Relationship, Drug
Female
Male
Motor Activity / drug effects*
Motor Skills / drug effects*
Noble Gases / pharmacology*
Pressure
Rats
Sleep / drug effects*
Time Factors
Wakefulness / drug effects*
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Noble Gases; 7440-37-1/Argon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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