| Biological effects of low intensity ultrasound: the mechanism involved, and its implications on therapy and on biosafety of ultrasound. | |
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MedLine Citation:
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PMID: 15635256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The biological effects of low intensity ultrasound (US) in vitro; the mechanisms involved; and the factors that can enhance or inhibit these effects are reviewed. The lowest possible US intensities required to induce cell killing or to produce free radicals were determined. Following sonication in the region of these intensities, the effects of US in combination with either hyperthermia, hypotonia, echo-contrast agents (ECA), CO2, incubation time, high cell density or various agents were examined. The results showed that hyperthermia, hypotonia and microbubbles are good enhancers of the bioeffects, while CO2, incubation time and high cell density are good inhibitors. Cellular membrane damage is pivotal in the events leading to cell death, with the cellular damage-and-repair mechanism as an important determinant of the fate of the damaged cells. The optimal level of apoptosis (with minimal lysis) and optimal gene transfection efficiency were attained using a pulsed low intensity US. In summary, the findings suggest that low intensity US is potentially useful in therapy, while on the other hand, they also call for further investigation of such clinical scenarios as high-grade fever, edema or use of ECA which may lead to the lowering of the threshold for bioeffects with diagnostic US. |
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Authors:
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Loreto B Feril; Takashi Kondo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of radiation research Volume: 45 ISSN: 0449-3060 ISO Abbreviation: J. Radiat. Res. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2005-01-06 Completed Date: 2005-05-12 Revised Date: 2012-03-28 |
Medline Journal Info:
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Nlm Unique ID: 0376611 Medline TA: J Radiat Res Country: Japan |
Other Details:
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Languages: eng Pagination: 479-89 Citation Subset: IM |
Affiliation:
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Department of Radiological Sciences, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Carbon Dioxide / metabolism Cell Membrane / metabolism Contrast Media / pharmacology DNA / metabolism Dose-Response Relationship, Drug Free Radicals Humans Hyperthermia, Induced Microbubbles Models, Biological Necrosis Sonication Temperature Transfection U937 Cells Ultrasonic Therapy / methods* Ultrasonics* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Free Radicals; 124-38-9/Carbon Dioxide; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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