Document Detail


Biological effects of low intensity ultrasound: the mechanism involved, and its implications on therapy and on biosafety of ultrasound.
MedLine Citation:
PMID:  15635256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The biological effects of low intensity ultrasound (US) in vitro; the mechanisms involved; and the factors that can enhance or inhibit these effects are reviewed. The lowest possible US intensities required to induce cell killing or to produce free radicals were determined. Following sonication in the region of these intensities, the effects of US in combination with either hyperthermia, hypotonia, echo-contrast agents (ECA), CO2, incubation time, high cell density or various agents were examined. The results showed that hyperthermia, hypotonia and microbubbles are good enhancers of the bioeffects, while CO2, incubation time and high cell density are good inhibitors. Cellular membrane damage is pivotal in the events leading to cell death, with the cellular damage-and-repair mechanism as an important determinant of the fate of the damaged cells. The optimal level of apoptosis (with minimal lysis) and optimal gene transfection efficiency were attained using a pulsed low intensity US. In summary, the findings suggest that low intensity US is potentially useful in therapy, while on the other hand, they also call for further investigation of such clinical scenarios as high-grade fever, edema or use of ECA which may lead to the lowering of the threshold for bioeffects with diagnostic US.
Authors:
Loreto B Feril; Takashi Kondo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of radiation research     Volume:  45     ISSN:  0449-3060     ISO Abbreviation:  J. Radiat. Res.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-01-06     Completed Date:  2005-05-12     Revised Date:  2012-03-28    
Medline Journal Info:
Nlm Unique ID:  0376611     Medline TA:  J Radiat Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  479-89     Citation Subset:  IM    
Affiliation:
Department of Radiological Sciences, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Carbon Dioxide / metabolism
Cell Membrane / metabolism
Contrast Media / pharmacology
DNA / metabolism
Dose-Response Relationship, Drug
Free Radicals
Humans
Hyperthermia, Induced
Microbubbles
Models, Biological
Necrosis
Sonication
Temperature
Transfection
U937 Cells
Ultrasonic Therapy / methods*
Ultrasonics*
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Free Radicals; 124-38-9/Carbon Dioxide; 9007-49-2/DNA

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