Document Detail


Biological effects of long-duration, high-field (4 T) MRI on growth and development in the mouse.
MedLine Citation:
PMID:  10931573     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of long-duration, high-field magnetic resonance imaging (MRI) on fetal growth and postnatal development in mice were studied. Seven experimental groups of pregnant ICR mice were exposed for 9 hours on day 9 and/or day 12 post coitus (pc) to magnetic fields (4 T static, 5 T/sec switched gradient, and 0.2 W/kg radiofrequency at 170 MHz) associated with MRI conditions. Two experimental groups (sham and exposure groups) were exposed to a combination of ultrasound (day 9 pc, 3.25 MHz, focused) and MRI-associated fields (day 12 pc). No statistically significant changes in fetal growth were observed in the animals exposed to only MRI or ultrasound fields. However, in the combined ultrasound and MRI-exposed group, the fetal weight and crown-rump length were reduced compared with the sham and cage controls. These results suggest that MRI and ultrasound exposure well in excess of current clinical conditions can exert biological effects if applied at sensitive stages of fetal development.
Authors:
R L Magin; J K Lee; A Klintsova; K I Carnes; F Dunn
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  12     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-12-05     Completed Date:  2000-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  140-9     Citation Subset:  IM    
Affiliation:
Magnetic Resonance Engineering Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana 61801, USA. rmagin@uic.edu
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Body Temperature
Body Weight / radiation effects
Electromagnetic Fields / adverse effects*
Embryonic and Fetal Development / radiation effects*
Female
Magnetic Resonance Imaging / adverse effects*,  methods
Maternal Exposure / adverse effects*
Mice
Models, Animal
Motor Skills / radiation effects*
Pregnancy
Pregnancy, Animal / radiation effects*
Reference Values
Survival Rate
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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