| Biological effects on granulosa cells of hydroxylated and methylated resveratrol analogues. | |
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MedLine Citation:
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PMID: 20140899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several resveratrol analogues have been designed to improve bioactivity: among these polymethoxystilbenes appear to be particularly promising. The present study was set up to investigate the biological functions of polymethoxystilbenes 2 and 3, recently found in our lab as antiangiogenic agents, on a well-defined swine granulosa cell model. Proliferative activity and effects on steroidogenesis were evaluated, as well as the effect on granulosa cell vascular endothelial growth factor (VEGF) production, since these cells in basic conditions synthesize the main proangiogenic peptide. Moreover, we considered the effect of these two resveratrol analogues on granulosa cell redox status. Analogue 3 inhibited granulosa cell growth, while it stimulated steroidogenesis. A similar effect was displayed by 2 on estradiol 17beta production and cell proliferation at the highest concentration tested. On the other hand, at the same dosage 2 decreased progesterone levels. Both analogues inhibited VEGF output. Granulosa cell redox status was unaffected by resveratrol analogue 2 while the highest concentration of 3 stimulated free radicals generation and scavenging enzyme activities. The overall results indicate that analogue 3 is the more powerful compound, thus suggesting that a slight modification in the structure markedly increases effectiveness. These data could be useful to develop more active resveratrol analogues for therapeutic use. |
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Authors:
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Giuseppina Basini; Corrado Tringali; Laura Baioni; Simona Bussolati; Carmela Spatafora; Francesca Grasselli |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular nutrition & food research Volume: 54 Suppl 2 ISSN: 1613-4133 ISO Abbreviation: Mol Nutr Food Res Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-29 Completed Date: 2010-12-08 Revised Date: 2013-06-03 |
Medline Journal Info:
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Nlm Unique ID: 101231818 Medline TA: Mol Nutr Food Res Country: Germany |
Other Details:
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Languages: eng Pagination: S236-43 Citation Subset: IM |
Affiliation:
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Dipartimento di Produzioni Animali, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti-Sezione di Fisiologia, Parma, Italy. basini@unipr.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiogenesis Inhibitors
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chemistry*,
pharmacology* Animals Cell Proliferation / drug effects Cell Survival Cells, Cultured Drug Evaluation, Preclinical Estradiol / metabolism Female Granulosa Cells / drug effects*, enzymology, metabolism Hydrogen Peroxide / metabolism Hydroxylation Methylation Osmolar Concentration Ovarian Follicle / cytology Oxidoreductases / metabolism Progesterone / metabolism Stilbenes / chemistry*, pharmacology* Superoxides / metabolism Sus scrofa Vascular Endothelial Growth Factors / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inhibitors; 0/Stilbenes; 0/Vascular Endothelial Growth Factors; 11062-77-4/Superoxides; 50-28-2/Estradiol; 57-83-0/Progesterone; 7722-84-1/Hydrogen Peroxide; EC 1.-/Oxidoreductases; Q369O8926L/resveratrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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