Document Detail


Biological effects of gestational and lactational PCB exposure in neonatal and juvenile C57BL/6 mice.
MedLine Citation:
PMID:  12520400     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to obtain a better understanding of polychlorinated biphenyl (PCB) immunotoxicity in the developing mouse. Adult female mice were dosed with three subcutaneous injections per week of 50 mg/kg Aroclor 1242 (A1242), Aroclor 1254 (A1254), or corn oil for 2 weeks and then mated with nondosed males. First-litter pups were sacrificed at 7 or 28 days of age. At both ages, the tissue concentration of PCB was significantly higher in both the A1242 and A1254 pups than in oil-treated controls. Seven-day-old pups exposed to A1242 or A1254 had significantly decreased splenic IL-2 production. Alterations in the percentages of T cell subsets compared to controls were observed in A1242-exposed pups; an increased spleen somatic index was noted only in A1254-exposed pups. Twenty-eight-day-old pups exposed to A1254 demonstrated a significant decrease in thymus somatic index, an increase in liver somatic index, a 25% decrease in total circulating T(4), and decreased B cell percentages relative to their controls. Alteration in the percentages of CD3(int) T cells was observed in A1254-exposed 28-day-old pups. A significant increase in 7-ethoxyresorufin- O-deethylase (EROD) and 7-benzoxyresorufin-O-dearylase (BROD) activity was measured at both ages in A1254-exposed pups and in A1242-exposed 28-day-old pups. These data confirm that during gestation and lactation A1242 and A1254 are transferred from dams to pups and that such exposure results in immune-related effects in neonatal (7-day-old) and juvenile (28-day-old) mice. Furthermore, A1254 exposure produces more frequent and pronounced effects than exposure to A1242.
Authors:
S M Arena; E H Greeley; R S Halbrook; L G Hansen; M Segre
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of environmental contamination and toxicology     Volume:  44     ISSN:  0090-4341     ISO Abbreviation:  Arch. Environ. Contam. Toxicol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-09     Completed Date:  2003-02-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0357245     Medline TA:  Arch Environ Contam Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  272-80     Citation Subset:  IM    
Affiliation:
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, 2001 South Lincoln Ave., Urbana, Illinois 61802, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Aroclors / administration & dosage,  adverse effects*
B-Lymphocytes
Chlorodiphenyl (54% Chlorine) / administration & dosage,  adverse effects*
Cytochrome P-450 CYP1A1 / drug effects,  pharmacology
Cytochrome P-450 CYP2B1 / drug effects,  pharmacology
Dose-Response Relationship, Drug
Environmental Pollutants / adverse effects*
Female
Immune System / drug effects*
Injections, Subcutaneous
Lactation
Mice
Mice, Inbred C57BL
Pregnancy
Prenatal Exposure Delayed Effects*
Spleen / cytology*,  pathology
T-Lymphocytes
Chemical
Reg. No./Substance:
0/Aroclors; 0/Environmental Pollutants; 11097-69-1/Chlorodiphenyl (54% Chlorine); 53469-21-9/aroclor 1242; EC 1.14.14.1/Cytochrome P-450 CYP1A1; EC 1.14.14.1/Cytochrome P-450 CYP2B1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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