Document Detail

Biological effects of environmentally relevant concentrations of the pharmaceutical Triclosan in the marine mussel Perna perna (Linnaeus, 1758).
MedLine Citation:
PMID:  22610038     Owner:  NLM     Status:  Publisher    
Triclosan (5-Chloro-2-(2,4-dichlorophenoxy) phenol) is an antibacterial compound widely employed in pharmaceuticals and personal care products. Although this emerging compound has been detected in aquatic environments, scarce information is found on the effects of Triclosan to marine organisms. The aim of this study was to evaluate the toxicity of a concentration range of Triclosan through fertilization assay (reproductive success), embryo-larval development assay (early life stage) and physiological stress (Neutral Red Retention Time assay - NRRT) (adult stage) in the marine sentinel organism Perna perna. The mean inhibition concentrations for fertilization (IC(50) = 0.490 mg L(-1)) and embryo-larval development (IC(50) = 0.135 mg L(-1)) tests were above environmental relevant concentrations (ng L(-1)) given by previous studies. Differently, significant reduction on NRRT results was found at 12 ng L(-1), demonstrating the current risk of the continuous introduction of Triclosan into aquatic environments, and the need of ecotoxicological studies oriented by the mechanism of action of the compound.
Fernando Sanzi Cortez; Camilo Dias Seabra Pereira; Aldo Ramos Santos; Augusto Cesar; Rodrigo Brasil Choueri; Gisela de Assis Martini; Maria Beatriz Bohrer-Morel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-18
Journal Detail:
Title:  Environmental pollution (Barking, Essex : 1987)     Volume:  168C     ISSN:  1873-6424     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804476     Medline TA:  Environ Pollut     Country:  -    
Other Details:
Languages:  ENG     Pagination:  145-150     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Instituto de Pesquisas Energéticas e Nucleares IPEN-CNEN/SP, 05508-000 São Paulo, SP, Brazil; Laboratório de Ecotoxicologia, Universidade Santa Cecília, 11045-907 Santos, SP, Brazil.
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