Document Detail


Biological effects of diesel exhaust particles (DEP) on isolated cardiac muscle of guinea pigs.
MedLine Citation:
PMID:  7531585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diesel engine-powered vehicles emit some 30 to 100 times more particles than do gasoline engine cars. We previously reported that diesel exhaust particles (DEP) could produce superoxide anions in an in vitro study. Furthermore, mice instilled intratracheally with DEP showed high mortality at low doses. The cause of death was lung edema with damage to the lung endothelial cells. In order to elucidate the mechanism of the onset of mortality induced by DEP, we examined the direct action of DEP on the isolated atrium of guinea pigs. A light-duty (2740cc), four cylinder diesel engine was used. The DEP were collected on fiberglass filter. DEP caused a negative inotropic action that was followed by the cardiac arrest of the isolated left atrium. These actions were not inhibited by propranolol, atropine, verapamil, diltiazem, diphenhydramine, indomethacin, superoxide dismutase or catalase. The precise mechanism of cardiac arrest is unknown. However, these results suggest that cardiac toxicity induced by DEP might be involved in lung edema.
Authors:
M Sakakibara; M Minami; T Endo; M Hirafuji; S Murakami; Y Mori; M Sagai
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Research communications in molecular pathology and pharmacology     Volume:  86     ISSN:  1078-0297     ISO Abbreviation:  Res. Commun. Mol. Pathol. Pharmacol.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-03-16     Completed Date:  1995-03-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9437512     Medline TA:  Res Commun Mol Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  99-110     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiotonic Agents / pharmacology
Guinea Pigs
Heart / drug effects*
Heart Arrest / chemically induced
Heart Atria / drug effects
Heart Rate / drug effects
Male
Myocardial Contraction / drug effects
Particle Size
Vehicle Emissions / toxicity*
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 0/Vehicle Emissions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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