| Biological effects of diesel exhaust particles (DEP) on isolated cardiac muscle of guinea pigs. | |
| | |
MedLine Citation:
|
PMID: 7531585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Diesel engine-powered vehicles emit some 30 to 100 times more particles than do gasoline engine cars. We previously reported that diesel exhaust particles (DEP) could produce superoxide anions in an in vitro study. Furthermore, mice instilled intratracheally with DEP showed high mortality at low doses. The cause of death was lung edema with damage to the lung endothelial cells. In order to elucidate the mechanism of the onset of mortality induced by DEP, we examined the direct action of DEP on the isolated atrium of guinea pigs. A light-duty (2740cc), four cylinder diesel engine was used. The DEP were collected on fiberglass filter. DEP caused a negative inotropic action that was followed by the cardiac arrest of the isolated left atrium. These actions were not inhibited by propranolol, atropine, verapamil, diltiazem, diphenhydramine, indomethacin, superoxide dismutase or catalase. The precise mechanism of cardiac arrest is unknown. However, these results suggest that cardiac toxicity induced by DEP might be involved in lung edema. |
| | |
Authors:
|
M Sakakibara; M Minami; T Endo; M Hirafuji; S Murakami; Y Mori; M Sagai |
Related Documents
:
|
15774075 - Bench-to-bedside review: ventilator strategies to reduce lung injury -- lessons from pe... 17060175 - Chronic airway disease: deteriorating pulmonary function in sheep associated with repea... 10988205 - High-frequency ventilation for acute lung injury and ards. 1592325 - A study on the diagnosis of drowning by examination of lung chlorophyll(a) of planktons... 21701165 - Nutrition of preterm infants after discharge. 15774075 - Bench-to-bedside review: ventilator strategies to reduce lung injury -- lessons from pe... |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: Research communications in molecular pathology and pharmacology Volume: 86 ISSN: 1078-0297 ISO Abbreviation: Res. Commun. Mol. Pathol. Pharmacol. Publication Date: 1994 Oct |
Date Detail:
|
Created Date: 1995-03-16 Completed Date: 1995-03-16 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9437512 Medline TA: Res Commun Mol Pathol Pharmacol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 99-110 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cardiotonic Agents / pharmacology Guinea Pigs Heart / drug effects* Heart Arrest / chemically induced Heart Atria / drug effects Heart Rate / drug effects Male Myocardial Contraction / drug effects Particle Size Vehicle Emissions / toxicity* |
| Chemical | |
Reg. No./Substance:
|
0/Cardiotonic Agents; 0/Vehicle Emissions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Agents of clinically significant bacteriuria
Next Document: Post-operative serial prostate-specific antigen and transrectal ultrasound for staging incidental ca...