Document Detail

Biological effects of acrylamide after daily ingestion of various foods in comparison to water: A study in rats.
MedLine Citation:
PMID:  20938989     Owner:  NLM     Status:  In-Data-Review    
Scope: Acrylamide (AA), classified as a genotoxic carcinogen, is generated by heating foods. We studied whether the food matrix modulates bioavailability and/or biotransformation and investigated kinetics and biological effectiveness of AA in rats. Methods and results: AA was given to the animals at a daily intake level of AA containing foods for up to 9 days, resulting in an exposure of 50 or 100 μg AA/kg body weight (b.w.)/day. Positive controls received the same dosages of AA in water, negative controls just water. As biomarkers urinary mercapturic acids, hemoglobin adducts, plasma levels of AA and glycidamide (GA) and DNA integrity in white blood cells and hepatocytes were measured. Altogether, no significant differences in bioavailability of AA from water and the different food matrices were observed. Only with bread crust, biomarkers indicated a slightly reduced bioavailability. Monitoring glycidamide valine adduct adducts did not provide evidence for treatment-related significantly enhanced GA-haemoglobin adduct formation in blood although glycidamide mercapturic acid excretion in urine indicated significant GA formation. Conclusions: The results suggest AA at dietary intake levels, exceeding estimated human mean intake by a factor of at least 100 to become detoxified in Sprague-Dawley rats to a major extent through glutathione coupling.
Franz Ingo Berger; Julia Feld; Daniel Bertow; Gerhard Eisenbrand; Gert Fricker; Natalie Gerhardt; Karl-Heinz Merz; Elke Richling; Matthias Baum
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Publication Detail:
Type:  Journal Article     Date:  2010-10-11
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  55     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  387-99     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Division of Food Chemistry and Toxicology, Department of Chemistry University of Kaiserslautern, Germany.
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