Document Detail


Biological effects of Echinacea purpurea on human blood cells.
MedLine Citation:
PMID:  19581209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to investigate radioprotective properties of Echinacea purpurea tablets in vivo. We analysed lymphocyte chromosome aberrations (CA), micronuclei (MN), apoptosis of leukocytes and haematological parameters in a group of radiation workers who were identified as carrying dicentric chromosomes in their lymphocytes. All radiation workers were taking two 275 mg Echinacea tablets b.i.d., according to a pharmacist's recommendation. All parameters were analysed before and after the two-week treatment. At the end of the treatment lymphocyte CA frequency dropped significantly, and the number of apoptotic cells increased. The inverse lymphocyte-to-granulocyte ratio at the beginning of the study changed to normal at its end. In conclusion, biological effects observed after administration of Echinacea purpurea preparation suggest that it may be beneficial for the prevention of adverse health effects in workers exposed to ionising radiation.
Authors:
Gordana Joksić; Sandra Petrović; Ivana Joksić; Andreja Leskovac
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arhiv za higijenu rada i toksikologiju     Volume:  60     ISSN:  0004-1254     ISO Abbreviation:  Arh Hig Rada Toksikol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-07     Completed Date:  2009-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373100     Medline TA:  Arh Hig Rada Toksikol     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  165-72     Citation Subset:  IM    
Affiliation:
Vinca Institute of Nuclear Sciences, Belgrade, Serbia. gjoksic@vinca.rs
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MeSH Terms
Descriptor/Qualifier:
Adult
Apoptosis / drug effects,  radiation effects
Blood Cell Count
Blood Cells / drug effects,  radiation effects*
Chromosome Breakage / drug effects
Echinacea*
Humans
Male
Micronucleus Tests
Occupational Exposure
Plant Preparations / pharmacology*
Radiation-Protective Agents / pharmacology*
Tablets
Chemical
Reg. No./Substance:
0/Plant Preparations; 0/Radiation-Protective Agents; 0/Tablets

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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