Document Detail


Biological disposition and imaging of a radioiodinated alkylphosphocholine in two rodent models of breast cancer.
MedLine Citation:
PMID:  8790215     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iodine-125-12-[m-iodophenyl]-dodecylphosphocholine (NM-324) has been shown to accumulate in a variety of animal tumor models. Moreover, preliminary pharmacokinetic studies with NM-324 are being conducted in cancer patients. The present study was undertaken to examine the potential application of NM-324 as a breast tumor-imaging agent. METHODS: Two animal models of breast cancer were utilized: namely, syngenic inbred Lewis female rats bearing the rat mammary tumor (RMT) and athymic mice with HT-39 human tumor xenografts. After i.v. administration of NM-324, the tissue distribution of radioactivity was determined at various time points. Gamma camera scintigrams were also acquired to confirm the biodistribution results. Macro- and microautoradiography were used to analyze cellular distribution of radioactivity in tumors. RESULTS: In the rat mammary tumor model, levels of radioactivity in the tumor reached a maximum at 24 hr after i.v. administration (1.65% ID/g, tumor-to-blood 6.4). These tumors could be visualized by gamma camera scintigraphy as early as 1 hour after administration. In the nude mouse model, levels of radioactivity in tumor reached a maximum at 48 hr after i.v. administration (4.96 %ID/g, tumor-to-blood 5.5). Tissues expected to interfere with the resolution of breast lesions such as fat, heart, lung and muscle displayed much lower concentrations of the radioactivity. Gamma camera scintigraphy confirmed the results observed from biodistribution experiments. Lipid extraction of the tumors and major organs in both animal models showed the sole presence of unchanged NM-324. Microautoradiographic analysis of slices of rat mammary and HT-39 tumors provided additional information regarding the intratumoral distribution of radioactivity. CONCLUSION: The ability of radioiodinated phospholipid analogs to accumulate in breast tumors reinforces the need for further investigation of this type of radiopharmaceutical as tumor imaging agents.
Authors:
M A Rampy; R S Brown; A N Pinchuk; J P Weichert; R W Skinner; S J Fisher; R L Wahl; M D Gross; S P Ethier; R E Counsell
Related Documents :
10874215 - Avidin chase can reduce myelotoxicity associated with radioimmunotherapy of experimenta...
11150765 - 8. a spherical coordinate system for tumor identification in positron emission tomograp...
19910425 - Pathophysiologic correlation between 62cu-atsm and 18f-fdg in lung cancer.
12508835 - The retention indices of 201tl-spect in brain tumors.
10338075 - Interstitial invasion of well-differentiated hepatocellular carcinoma and subsequent tu...
8279755 - Breast carcinoma and the role of iron metabolism. a cytochemical, tissue culture, and u...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  37     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-10-21     Completed Date:  1996-10-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1540-5     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109-0632, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Female
Humans
Iodine Radioisotopes / diagnostic use*,  pharmacokinetics
Mammary Neoplasms, Experimental / radionuclide imaging*
Mice
Mice, Nude
Phospholipid Ethers / diagnostic use*,  pharmacokinetics
Rats
Rats, Inbred Lew
Tissue Distribution
Transplantation, Heterologous
Grant Support
ID/Acronym/Agency:
CA-08349/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Phospholipid Ethers; 144796-42-9/NM 324

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Somatostatin-receptor scintigraphy of subcutaneous and thyroid metastases from bronchial carcinoid.
Next Document:  Intraperitoneal indium-111- and yttrium-90-labeled human IgM (AC6C3-2B12) in nude mice bearing perit...