Document Detail

Biological and clinical aspects of interleukin 6.
MedLine Citation:
PMID:  2127356     Owner:  NLM     Status:  MEDLINE    
Interleukin 6 (IL-6) is a multi-functional cytokine that is produced by a range of cells and plays a central role in host defense mechanisms. Abnormal production of IL-6 has been suggested to be involved in glomerulonephritis, plasmacytomagenesis and in the pathogenesis of autoimmune diseases. In this review, Toshio Hirano and colleagues discuss the possible involvement of IL-6 in a variety of diseases, the regulatory mechanism(s) of expression of the IL-6 gene and the structure and function of the IL-6 receptor.
T Hirano; S Akira; T Taga; T Kishimoto
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Immunology today     Volume:  11     ISSN:  0167-5699     ISO Abbreviation:  Immunol. Today     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-04-17     Completed Date:  1991-04-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8008346     Medline TA:  Immunol Today     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  443-9     Citation Subset:  IM    
Division of Immunology, Osaka University, Japan.
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MeSH Terms
Acute-Phase Reaction
Autoimmune Diseases / etiology
Gene Expression Regulation
Glomerulonephritis / etiology
Interleukin-6 / genetics,  physiology*
Mice, Transgenic
Multiple Myeloma / etiology
Receptors, Immunologic / analysis
Receptors, Interleukin-6
Reg. No./Substance:
0/Interleukin-6; 0/Receptors, Immunologic; 0/Receptors, Interleukin-6
Comment In:
Immunol Today. 1991 May;12(5):170   [PMID:  1750926 ]

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