Document Detail


Biological characteristics of neuroblastoma with spontaneous tumor reduction: a case report.
MedLine Citation:
PMID:  7623238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors examined the biological characteristics of a neuroblastoma with spontaneous tumor reduction. A 6-month-old boy with a pelvic neuroblastoma underwent surgical extirpation of the tumor 1 month after diagnosis. The size of the tumor reduced spontaneously while he was awaiting operation. The low proliferative activity of the tumor cells and the presence of apoptosis in the tumor tissue were shown by an immunohistochemical method using anti-PCNA antibody and a DNA fragmentation analysis, respectively. These results suggest that the spontaneous tumor reduction seen in this patient may well be caused by the overwhelming apoptosis of tumor cells.
Authors:
M Iwata; T Koshinaga; I Okabe; Y Kurosu; M Esumi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  30     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-08-31     Completed Date:  1995-08-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  722-3     Citation Subset:  IM    
Affiliation:
First Department of Surgery, Nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Apoptosis*
DNA Damage
DNA, Neoplasm
Humans
Infant
Male
Neoplasm Regression, Spontaneous / physiopathology*
Neuroblastoma / genetics,  physiopathology*
Pelvic Neoplasms / genetics,  physiopathology*
Proliferating Cell Nuclear Antigen
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 0/Proliferating Cell Nuclear Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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