| Biological applications of microfluidic gradient devices. | |
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MedLine Citation:
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PMID: 20957276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Molecular gradients play an important role in diverse physiological and pathological phenomena such as immune response, wound healing, development and cancer metastasis. In the past 10 years, engineering tools have been increasingly used to develop experimental platforms that capture important aspects of cellular microenvironments to allow quantitative and reproducible characterization of cellular response to gradients. This review discusses the emergence of microfluidics-based gradient generators and their applications in enhancing our understanding of fundamental biological processes such as chemotaxis and morphogenesis. The principles and applications of microfluidic gradient generation in both 2D and 3D cellular microenvironments are discussed with emphasis on approaches to manipulate spatial and temporal distribution of signaling molecules. |
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Authors:
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Sudong Kim; Hyung Joon Kim; Noo Li Jeon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-10-19 |
Journal Detail:
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Title: Integrative biology : quantitative biosciences from nano to macro Volume: 2 ISSN: 1757-9708 ISO Abbreviation: Integr Biol (Camb) Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-02 Completed Date: 2011-02-18 Revised Date: 2011-08-22 |
Medline Journal Info:
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Nlm Unique ID: 101478378 Medline TA: Integr Biol (Camb) Country: England |
Other Details:
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Languages: eng Pagination: 584-603 Citation Subset: IM |
Affiliation:
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School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Axons / physiology Biomedical Engineering Chemokines / physiology Chemotaxis Dictyostelium / physiology Diffusion Equipment Design Escherichia coli / physiology Extracellular Matrix / physiology Humans Hydrogels Immunity Microfluidic Analytical Techniques / instrumentation*, methods Models, Biological Morphogenesis Neoplasm Metastasis Neovascularization, Physiologic Signal Transduction Stem Cells / cytology, physiology |
| Chemical | |
Reg. No./Substance:
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0/Chemokines; 0/Hydrogels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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