| Biological activity resulting from exposure to aquatic environmental genotoxic pollutants in northern Egypt. | |
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MedLine Citation:
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PMID: 20214163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We estimated pollution in Lake Edku and the Mediterranean Sea, El-Maadiya Region, with 3 aromatic amines (1-naphthylamine, 2-naphthylamine and benzidine) in the muscle tissue of fish. There were marked seasonal variations in the aromatic amine levels. We also determined oxidative stress (blood glutathione, and catalase activity) and genotoxic effects (chromosomal aberrations and urinary metabolites) in fishermen from each area. The fishermen suffered from oxidative stress and had high levels of the urinary metabolite sulfanilamide [mean (microg/mg creatinine): Lake Edku 20.7, Mediterranean 14.5, controls 5.3]. Frequencies for total chromosomal aberrations were significantly raised in the peripheral blood lymphocytes of fishermen in both areas [frequency (per 100 metaphases): Mediterranean 67, Lake Edku 45, controls 14]. |
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Authors:
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A A Saad; A M El-Sikaily; S F Kholeif; E S Khalil; H S Mahrous; E M S Al-Zabedi; H A Kassem |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Eastern Mediterranean health journal = La revue de sant? de la M?diterran?e orientale = al-Majallah al-?i???yah li-sharq al-mutawassi? Volume: 16 ISSN: 1020-3397 ISO Abbreviation: East. Mediterr. Health J. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-03-10 Completed Date: 2010-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9608387 Medline TA: East Mediterr Health J Country: Egypt |
Other Details:
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Languages: eng Pagination: 82-8 Citation Subset: IM |
Affiliation:
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Department of Applied Medical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Naphthylamine
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adverse effects,
analysis 2-Naphthylamine / adverse effects, analysis Adult Animals Benzidines / adverse effects, analysis Case-Control Studies Catalase / blood Chromosome Aberrations / statistics & numerical data DNA Damage / physiology Egypt / epidemiology Environmental Exposure / adverse effects, analysis* Environmental Monitoring / methods Fisheries* Fishes* / metabolism Fresh Water / analysis*, chemistry Glutathione / blood Humans Male Mediterranean Sea / epidemiology Oxidative Stress / physiology Seasons Water Pollutants, Chemical / adverse effects, analysis* |
| Chemical | |
Reg. No./Substance:
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0/Benzidines; 0/Water Pollutants, Chemical; 134-32-7/1-Naphthylamine; 70-18-8/Glutathione; 91-59-8/2-Naphthylamine; 92-87-5/benzidine; EC 1.11.1.6/Catalase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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