Document Detail

Biological activity resulting from exposure to aquatic environmental genotoxic pollutants in northern Egypt.
MedLine Citation:
PMID:  20214163     Owner:  NLM     Status:  MEDLINE    
We estimated pollution in Lake Edku and the Mediterranean Sea, El-Maadiya Region, with 3 aromatic amines (1-naphthylamine, 2-naphthylamine and benzidine) in the muscle tissue of fish. There were marked seasonal variations in the aromatic amine levels. We also determined oxidative stress (blood glutathione, and catalase activity) and genotoxic effects (chromosomal aberrations and urinary metabolites) in fishermen from each area. The fishermen suffered from oxidative stress and had high levels of the urinary metabolite sulfanilamide [mean (microg/mg creatinine): Lake Edku 20.7, Mediterranean 14.5, controls 5.3]. Frequencies for total chromosomal aberrations were significantly raised in the peripheral blood lymphocytes of fishermen in both areas [frequency (per 100 metaphases): Mediterranean 67, Lake Edku 45, controls 14].
A A Saad; A M El-Sikaily; S F Kholeif; E S Khalil; H S Mahrous; E M S Al-Zabedi; H A Kassem
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Eastern Mediterranean health journal = La revue de sant? de la M?diterran?e orientale = al-Majallah al-?i???yah li-sharq al-mutawassi?     Volume:  16     ISSN:  1020-3397     ISO Abbreviation:  East. Mediterr. Health J.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9608387     Medline TA:  East Mediterr Health J     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  82-8     Citation Subset:  IM    
Department of Applied Medical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt.
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MeSH Terms
1-Naphthylamine / adverse effects,  analysis
2-Naphthylamine / adverse effects,  analysis
Benzidines / adverse effects,  analysis
Case-Control Studies
Catalase / blood
Chromosome Aberrations / statistics & numerical data
DNA Damage / physiology
Egypt / epidemiology
Environmental Exposure / adverse effects,  analysis*
Environmental Monitoring / methods
Fishes* / metabolism
Fresh Water / analysis*,  chemistry
Glutathione / blood
Mediterranean Sea / epidemiology
Oxidative Stress / physiology
Water Pollutants, Chemical / adverse effects,  analysis*
Reg. No./Substance:
0/Benzidines; 0/Water Pollutants, Chemical; 134-32-7/1-Naphthylamine; 70-18-8/Glutathione; 91-59-8/2-Naphthylamine; 92-87-5/benzidine; EC

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