Document Detail


Biological activity of oestradiol sulphate in an oviparous amniote: implications for maternal steroid effects.
MedLine Citation:
PMID:  21106590     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Understanding the many factors that underlie phenotypic variation is of profound importance to evolutionary biologists. The embryonic endocrine environment is one such factor that has received much attention. In placental amniotes, the dynamic interaction of maternal and embryonic steroid production and metabolism is critical to regulating the endocrine environment. Less is known about how embryos of oviparous amniotes regulate their endocrine environment because most studies have focused on relating initial steroid levels in the yolk at oviposition to offspring phenotype. We tested the hypothesis that embryos of oviparous amniotes regulate their endocrine environment by conjugating maternal steroids and subsequently using the metabolites as precursors for steroid production later in development. Using the red-eared slider turtle (Trachemys scripta), we first characterized the conjugation of exogenous oestradiol to either oestradiol glucuronide or oestradiol sulphate (E(2)-S) in ovo during the first 15 days of development. Results show that oestradiol is primarily conjugated to E(2)-S. We then examined whether E(2)-S influenced sex determination and report that E(2)-S increases the production of female offspring. These data demonstrate that oviparous amniotes can both sulphonate steroids and respond to sulphonated steroids during embryonic development in a manner similar to placental amniotes.
Authors:
Ryan T Paitz; Rachel M Bowden
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-11-24
Journal Detail:
Title:  Proceedings. Biological sciences / The Royal Society     Volume:  278     ISSN:  1471-2954     ISO Abbreviation:  Proc. Biol. Sci.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-05-26     Completed Date:  2011-10-03     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101245157     Medline TA:  Proc Biol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2005-10     Citation Subset:  IM    
Affiliation:
School of Biological Sciences, Illinois State University, Normal, IL 61790, USA. rpaitz@ilstu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Embryo, Nonmammalian / metabolism
Estradiol / analogs & derivatives*,  metabolism*
Female
Illinois
Male
Oviparity
Ovum / metabolism
Random Allocation
Reproduction
Sex Ratio
Turtles / growth & development*,  metabolism*
Chemical
Reg. No./Substance:
28814-94-0/estradiol sulfate; 50-28-2/Estradiol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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