Document Detail


Biological activity of the e domain of the IGF-1Ec as addressed by synthetic peptides.
MedLine Citation:
PMID:  24776619     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Insulin-like growth factor-1 (IGF-1) is a multipotent growth factor involved in the growth, development and regulation of homeostasis in a tissue-specific manner. Alternative splicing, multiple transcription initiation sites and different polyadelynation signals give rise to diverse mRNA isoforms, such as IGF-1Ea, IGF-1Eb and IGF-1Ec transcripts. There is increasing interest in the expression of the IGF-1 isoforms and their potential distinct biological role. IGF-1Ec results from alternative splicing of exons 4-5-6 and its expression is upregulated in various conditions and pathologies. Recent studies have shown that IGF-1Ec is preferentially increased after injury in skeletal muscle during post-infarctal myocardium remodelling and in cancer tissues and cell lines. A synthetic analogue corresponding to the last 24 aa of the E domain of the IGF-1Ec isoform has been used to elucidate its potential biological role. The aim of the present review is to describe and discuss the putative bioactivity of the E domain of the IGF-1Ec isoform.
Authors:
George Vassilakos; Anastassios Philippou; Panagiotis Tsakiroglou; Michael Koutsilieris
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Publication Detail:
Type:  REVIEW    
Journal Detail:
Title:  Hormones (Athens, Greece)     Volume:  13     ISSN:  1109-3099     ISO Abbreviation:  Hormones (Athens)     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101142469     Medline TA:  Hormones (Athens)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  182-196     Citation Subset:  -    
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