Document Detail

Biological activity of C-peptide on the skin microcirculation in patients with insulin-dependent diabetes mellitus.
MedLine Citation:
PMID:  9593759     Owner:  NLM     Status:  MEDLINE    
19 insulin-dependent diabetes mellitus (IDDM) patients participated in a randomized double-blind crossover investigation to investigate the impact of human C-peptide on skin microvascular blood flow. The investigation was also carried out with 10 healthy volunteers. Blood pressure, heart rate, blood sugar, and C-peptide levels were monitored during a 60-min intravenous infusion period of C-peptide (8 pmol kg-1 min-1) or saline solution (154 mmol liter-1 NaCl), and 30 min after stopping the infusion. During the same time period, capillary blood cell velocity (CBV), laser Doppler flux (LDF), and skin temperature were assessed in the feet. In the verum arm, C-peptide levels increased after starting infusion to reach a maximum of 2.3+/-0.2 nmol liter-1 after 45 min, but remained below 0. 15 nmol liter-1 during the saline treatment. Baseline CBV was lower in diabetic patients compared with healthy subjects (147+/-3.6 vs. 162+/-4.2 micron s-1; P < 0.01). During C-peptide administration, CBV in IDDM patients increased progressively from 147+/-3.6 to 167+/-3.7 micron s-1; P < 0.001), whereas no significant change occurred during saline infusion or in healthy subjects. In contrast to the CBV measurements, the investigation of LDF, skin temperature, blood pressure, heart rate, or blood sugar did not demonstrate any significant change during the study. Replacement of human C-peptide in IDDM patients leads to a redistribution in skin microvascular blood flow levels comparable to levels in healthy subjects by increasing the nutritive CBV relative to subpapillary arteriovenous shunt flow.
T Forst; T Kunt; T Pohlmann; K Goitom; M Engelbach; J Beyer; A Pfützner
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  101     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-06-19     Completed Date:  1998-06-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2036-41     Citation Subset:  AIM; IM    
University Hospital Mainz, Department of Internal Medicine, Endocrinology and Metabolism, D-55101 Mainz, Germany.
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MeSH Terms
Blood Flow Velocity / drug effects
Blood Glucose / analysis
Blood Pressure / drug effects
C-Peptide / blood,  pharmacology*
Diabetes Mellitus, Type 1 / physiopathology*
Foot / blood supply
Heart Rate / drug effects
Infusions, Intravenous
Insulin / blood
Microcirculation / drug effects*
Middle Aged
Regional Blood Flow / drug effects
Skin / blood supply*
Skin Temperature / drug effects
Reg. No./Substance:
0/Blood Glucose; 0/C-Peptide; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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