Document Detail

Biological activity of 1-deazapurine nucleosides: role of deoxycytidine kinase?
MedLine Citation:
PMID:  10432706     Owner:  NLM     Status:  MEDLINE    
Several 1-deazapurine nucleosides were tested for their biological activity, anti-HIV-1, cytotoxicity and inhibition of adenosine deaminase (ADA). A2780 human ovarian cancer cells and the deoxycytidine kinase (dCK) deficient variant AG6000, used to determine whether dCK plays a role in their activation, showed a similar sensitivity to the analogs. This is in line with substrate specificity tests, which revealed a very low affinity of dCK.
A M Bergman; G Cristalli; S Vittori; J Wang; S Eriksson; G J Peters
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nucleosides & nucleotides     Volume:  18     ISSN:  0732-8311     ISO Abbreviation:  Nucleosides Nucleotides     Publication Date:    1999 Apr-May
Date Detail:
Created Date:  1999-08-24     Completed Date:  1999-08-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8215930     Medline TA:  Nucleosides Nucleotides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  897-8     Citation Subset:  IM; X    
Dept. Oncology, University Hospital VU, Amsterdam, The Netherlands.
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MeSH Terms
Adenosine Deaminase / antagonists & inhibitors
Aza Compounds / chemistry
Cell Division
Deoxycytidine Kinase / metabolism*
HIV-1 / drug effects
Ovarian Neoplasms / pathology
Purine Nucleosides / chemistry,  pharmacology*
Substrate Specificity
Tumor Cells, Cultured
Reg. No./Substance:
0/Aza Compounds; 0/Purine Nucleosides; EC Kinase; EC Deaminase

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