Document Detail

Biological activities of purified marennine, the blue pigment responsible for the greening of oysters.
MedLine Citation:
PMID:  22423636     Owner:  NLM     Status:  Publisher    
Marennine, the blue pigment produced by the diatom Haslea ostrearia, exists in two different forms, the intracellular and extracellular forms. We investigated the antibacterial, antiviral and antiproliferative properties of both these forms. Both forms of marennine inhibited the development of marine bacteria, in particular the pathogenic organism Vibrio aesturianus, at concentrations as low as 1 µg/mL, but they did not display any effect on a wide range of pathogenic bacteria that are relevant for food safety. Both forms of the pigment produced by H. ostrearia also exhibited antiviral activity against the HSV1 herpes virus, with intracellular and extracellular marennine having EC50 values of 24.0 and 27.0 µg/mL, respectively. These values are two orders of magnitude higher than the value for the reference drug, Zovirax. Moreover, both forms of marennine were effective in slowing or inhibiting the proliferation of cancer cells. This study confirms the potential of marennine as a biologically active organic molecule, which could have a protective effect on bivalves, which filter seawater and fix the pigment on their gills. Moreover, marennine could be used in food engineering and chemistry as a natural blue pigment, and also considered for use as a nutraceutical, as it is eaten and possibly assimilated by green oyster consumers.
Romain Gastineau; Jean-Bernard Pouvreau; Claire Hellio; Michèle Morançais; Joel Fleurence; Pierre Gaudin; Nathalie Bourgougnon; Jean-Luc Mouget
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-19
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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