Document Detail


Biological activities of phthalocyanines--XI. Phototoxicity of sulfonated aluminum naphthalocyanines towards V-79 Chinese hamster cells.
MedLine Citation:
PMID:  2356226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The phototoxicity of sulfonated aluminum naphthalocyanines towards V-79 Chinese hamster cells is investigated. The disulfonated naphthalocyanine exhibits similar photostability, but better cell penetrating properties than the tetrasulfonated dyes. The capacity of the naphthalocyanines to generate singlet oxygen is comparable to that of the corresponding phthalocyanines. However, in contrast to the phthalocyanine dyes, the sulfonated aluminum naphthalocyanines show very little phototoxicity towards the V-79 cells, suggesting close association with non-vital cell constituents or extensive formation of photoinactive adducts and aggregates.
Authors:
B Paquette; H Ali; R Langlois; J E van Lier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  51     ISSN:  0031-8655     ISO Abbreviation:  Photochem. Photobiol.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-07-20     Completed Date:  1990-07-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  313-7     Citation Subset:  IM    
Affiliation:
MRC Group in the Radiation Sciences, Faculty of Medicine, University of Sherbrooke, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Aluminum / toxicity*
Animals
Cell Line
Cell Survival / drug effects*,  radiation effects
Cricetinae
Cricetulus
Indoles / toxicity
Lung
Naphthalenes / toxicity
Organometallic Compounds / toxicity*
Photochemistry
Chemical
Reg. No./Substance:
0/Indoles; 0/Naphthalenes; 0/Organometallic Compounds; 7429-90-5/Aluminum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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