Document Detail


Biological activities of lipoteichoic acid and peptidoglycan-teichoic acid of Bacillus subtilis 168 (Marburg).
MedLine Citation:
PMID:  8277249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the suitability of Bacillus subtilis as a production host of heterologous proteins for pharmaceutical purposes, we assessed the biological activity of this bacterium and its major cell envelope components, lipoteichoic acid (LTA) and peptidoglycan-teichoic acid complex (PG-TA) in several eukaryotic effector assays. LTA and PG-TA were found to be non-toxic for mice and guinea-pigs in a short-term toxicity assay. PG-TA was weakly pyrogenic and weakly mitogenic. Both LTA and PG-TA acted as immunologic adjuvants in mice and when injected in mice, also caused an increase in the number of granulocyte-monocyte colony-forming cells in the bone marrow probably via stimulation of production of granulocyte-macrophage colony-stimulating factor.
Authors:
J P Himanen; L Pyhälä; R M Olander; O Merimskaya; T Kuzina; O Lysyuk; A Pronin; A Sanin; I M Helander; M Sarvas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of general microbiology     Volume:  139     ISSN:  0022-1287     ISO Abbreviation:  J. Gen. Microbiol.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-02-08     Completed Date:  1994-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375371     Medline TA:  J Gen Microbiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2659-65     Citation Subset:  IM    
Affiliation:
National Public Health Institute, Helsinki, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / pharmacology
Animals
Bacillus subtilis / chemistry*
Female
Granulocyte-Macrophage Colony-Stimulating Factor / drug effects
Guinea Pigs
Limulus Test
Lipopolysaccharides / chemistry*,  pharmacology,  toxicity
Male
Mice
Mice, Inbred BALB C
Mice, Inbred CBA
Mitogens / pharmacology
Peptidoglycan / chemistry*,  pharmacology,  toxicity
Pyrogens / toxicity
Rabbits
Teichoic Acids / chemistry*,  pharmacology,  toxicity
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Lipopolysaccharides; 0/Mitogens; 0/Peptidoglycan; 0/Pyrogens; 0/Teichoic Acids; 56411-57-5/lipoteichoic acid; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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