| Biological actions of green tea catechins on cardiac troponin C. | |
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MedLine Citation:
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PMID: 20977454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Catechins, biologically active polyphenols in green tea, are known to have a protective effect against cardiovascular diseases. In this study, we investigated direct actions of green tea catechins on cardiac muscle function to explore their uses as potential drugs for cardiac muscle disease. EXPERIMENTAL APPROACH: The effects of catechins were systematically investigated on the force-pCa relationship in skinned cardiac muscle fibres to determine their direct effects on cardiac myofilament contractility. The mechanisms of action of effective catechins were investigated using troponin exchange techniques, quartz crystal microbalance, nuclear magnetic resonance and a transgenic mouse model. KEY RESULTS: (-)-Epicatechin-3-gallate (ECg) and (-)-epigallocatechin-3-gallate (EGCg), but not their stereoismers (-)-catechin-3-gallate and (-)-gallocatechin-3-gallate, decreased cardiac myofilament Ca(2+) sensitivity probably through its interaction with cardiac troponin C. EGCg restored cardiac output in isolated working hearts by improving diastolic dysfunction caused by increased myofilament Ca(2+) sensitivity in a mouse model of hypertrophic cardiomyopathy. CONCLUSIONS AND IMPLICATIONS: The green tea catechins, ECg and EGCg, are Ca(2+) desensitizers acting through binding to cardiac troponin C. These compounds might be useful compounds for the development of therapeutic agents to treat the hypertrophic cardiomyopathy caused by increased Ca(2+) sensitivity of cardiac myofilaments. |
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Authors:
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Naoto Tadano; Cheng-Kun Du; Fumiaki Yumoto; Sachio Morimoto; Mika Ohta; Ming-Fang Xie; Koji Nagata; Dong-Yun Zhan; Qun-Wei Lu; Yoshikazu Miwa; Fumi Takahashi-Yanaga; Masaru Tanokura; Iwao Ohtsuki; Toshiyuki Sasaguri |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of pharmacology Volume: 161 ISSN: 1476-5381 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-27 Completed Date: 2011-02-10 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 1034-43 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. British Journal of Pharmacology © 2010 The British Pharmacological Society. |
Affiliation:
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Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism Cardiomyopathy, Hypertrophic / drug therapy*, physiopathology Catechin / analogs & derivatives, isolation & purification, pharmacology* Disease Models, Animal Humans Magnetic Resonance Spectroscopy Male Mice Mice, Inbred C57BL Mice, Transgenic Microfilaments / drug effects, metabolism Myocardial Contraction / drug effects Quartz Crystal Microbalance Techniques Rabbits Stereoisomerism Tea / chemistry* Troponin C / drug effects*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Tea; 0/Troponin C; 154-23-4/Catechin; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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