Document Detail

Biological actions of green tea catechins on cardiac troponin C.
MedLine Citation:
PMID:  20977454     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Catechins, biologically active polyphenols in green tea, are known to have a protective effect against cardiovascular diseases. In this study, we investigated direct actions of green tea catechins on cardiac muscle function to explore their uses as potential drugs for cardiac muscle disease.
EXPERIMENTAL APPROACH: The effects of catechins were systematically investigated on the force-pCa relationship in skinned cardiac muscle fibres to determine their direct effects on cardiac myofilament contractility. The mechanisms of action of effective catechins were investigated using troponin exchange techniques, quartz crystal microbalance, nuclear magnetic resonance and a transgenic mouse model.
KEY RESULTS: (-)-Epicatechin-3-gallate (ECg) and (-)-epigallocatechin-3-gallate (EGCg), but not their stereoismers (-)-catechin-3-gallate and (-)-gallocatechin-3-gallate, decreased cardiac myofilament Ca(2+) sensitivity probably through its interaction with cardiac troponin C. EGCg restored cardiac output in isolated working hearts by improving diastolic dysfunction caused by increased myofilament Ca(2+) sensitivity in a mouse model of hypertrophic cardiomyopathy.
CONCLUSIONS AND IMPLICATIONS: The green tea catechins, ECg and EGCg, are Ca(2+) desensitizers acting through binding to cardiac troponin C. These compounds might be useful compounds for the development of therapeutic agents to treat the hypertrophic cardiomyopathy caused by increased Ca(2+) sensitivity of cardiac myofilaments.
Naoto Tadano; Cheng-Kun Du; Fumiaki Yumoto; Sachio Morimoto; Mika Ohta; Ming-Fang Xie; Koji Nagata; Dong-Yun Zhan; Qun-Wei Lu; Yoshikazu Miwa; Fumi Takahashi-Yanaga; Masaru Tanokura; Iwao Ohtsuki; Toshiyuki Sasaguri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of pharmacology     Volume:  161     ISSN:  1476-5381     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-27     Completed Date:  2011-02-10     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1034-43     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. British Journal of Pharmacology © 2010 The British Pharmacological Society.
Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Actin Cytoskeleton / drug effects,  metabolism
Calcium / metabolism
Cardiomyopathy, Hypertrophic / drug therapy*,  physiopathology
Catechin / analogs & derivatives,  isolation & purification,  pharmacology*
Disease Models, Animal
Magnetic Resonance Spectroscopy
Mice, Inbred C57BL
Mice, Transgenic
Myocardial Contraction / drug effects
Quartz Crystal Microbalance Techniques
Tea / chemistry*
Troponin C / drug effects*,  metabolism
Reg. No./Substance:
0/Tea; 0/Troponin C; 154-23-4/Catechin; 7440-70-2/Calcium

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