Document Detail


Biological actions of drugs affecting serotonin and eating.
MedLine Citation:
PMID:  8697044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present status of knowledge on drugs affecting food intake and presumably acting via a serotoninergic mechanism is reviewed. The mechanism of action of these drugs is analyzed at the neurochemical level. All the drugs, to various extents, inhibit the uptake of serotonin (5HT), increase the release of 5HT and decrease brain levels of 5HT and 5HIAA. However, the underlying mechanisms are not identical as exemplified by comparisons made with d-fenfluramine, d-norfenfluramine, fluoxetine, sertraline and paroxetine. An analysis of the role of 5HT in the inhibition of food intake reveals that only d-fenfluramine is inhibited by antiserotonin agents. The role of the different 5HT receptor-subtypes in this antagonism is discussed. More selective 5HT antagonists are needed to establish which 5HT receptor(s) controls food intake.
Authors:
S Garattini
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Obesity research     Volume:  3 Suppl 4     ISSN:  1071-7323     ISO Abbreviation:  Obes. Res.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-09-05     Completed Date:  1996-09-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9305691     Medline TA:  Obes Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  463S-470S     Citation Subset:  IM    
Affiliation:
Istituto di Ricerche Farmacologiche Mario Negri Via Eritrea, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Depressants / pharmacology*
Eating / drug effects*
Fenfluramine / pharmacology
Humans
Norfenfluramine / pharmacology
Serotonin / metabolism,  physiology*
Serotonin Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Serotonin Agents; 1886-26-6/Norfenfluramine; 458-24-2/Fenfluramine; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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