| A biological phantom for contrast-media-based perfusion studies with CT. | |
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MedLine Citation:
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PMID: 19724231 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Perfusion computed tomography (PCT) is increasingly getting popular with the advent of computed tomography (CT) systems with adequate temporal resolution and spatial coverage. We sought to develop a biological phantom for perfusion measurements in CT to design, improve, and validate scan protocols and postprocessing algorithms in vitro. MATERIALS AND METHODS: A special technique was applied to prepare and preserve a fresh porcine kidney. The kidney was connected to an open circuit driven by a peristaltic pump with the option to inject contrast material. We evaluated repeated dynamic contrast-enhanced CT acquisitions with different input flow rates and the relation to calculated parenchymal flow results of the phantom. Flow was calculated with 2 different algorithms. Identical scans were performed with a time interval of 1 year to check long-term stability of the phantom. Different bolus geometries were designed and bolus dispersion was measured for the setup using a tubing array. RESULTS: We found a linear relationship between the input flow rate of the circuit and the calculated phantom tissue flow with a correlation coefficient rr2 = 0.99 for both algorithms. Both algorithms resulted in very similar absolute values, the mean difference was 3.1 mL/100 mL/min. Perfusion measurements with contrast material injection and storage did not alter the phantom. The enhancement properties did not change over the time of 1 year. With our setup, it was possible to design typical bolus geometries as they occur in clinical practice. Bolus dispersion was small: peak enhancement and bolus width changed by about only 5% over 2-m tube length. CONCLUSIONS: A phantom for parenchymal flow measurements suitable for repeated measurements over a long period of time was developed. The setup allows the design of diverse bolus geometries with negligible dispersion. |
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Authors:
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Ulrike Haberland; Jens Cordes; Michael Lell; Nasreddin Abolmaali; Ernst Klotz |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Investigative radiology Volume: 44 ISSN: 1536-0210 ISO Abbreviation: Invest Radiol Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2010-04-12 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 676-82 Citation Subset: IM |
Affiliation:
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OncoRay-Center for Radiation Research in Oncology, TU Dresden, Germany. ulrike.haberland.ext@siemens.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Media* Equipment Design Equipment Failure Analysis Kidney / radiography* Perfusion Imaging / instrumentation* Phantoms, Imaging* Swine Tomography, X-Ray Computed / instrumentation* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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