| Biological Evaluation of Dodecaborate-Containing L-Amino Acids for Boron Neutron Capture Therapy. | |
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MedLine Citation:
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PMID: 22788992 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In order to develop a boron carrier for practical purposes, new boron-containing amino acids with an undecahydro-closo-dodecaboranylthio ([(10)B(12)H(11)S](2-)-) unit in the side chain of the a-amino acid have already been designed and synthesized. In the present paper, cytotoxicity, the incorporation amounts into tumor cells, and the tumor cell killing effects of these compounds were elucidated to evaluate their usefulness as boron carriers. Furthermore, the microdistribution of the amino acids in tumor cells was established. |
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Authors:
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Yoshihide Hattori; Shintaro Kusaka; Mari Mukumoto; Kouki Uehara; Tomoyuki Asano; Minoru Suzuki; Shin-Ichiro Masunaga; Koji Ono; Shinji Tanimori; Mitsunori Kirihata |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-12 |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: - ISSN: 1520-4804 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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