| Biological basis of depression in adults with diabetes. | |
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MedLine Citation:
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PMID: 20878274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diabetes and depression are common comorbid conditions. Although certain health behaviors and risk factors partially explain the association of depression and diabetes, other potential mechanisms have yet to be elucidated. Certain neuroendocrine alterations such as activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) may contribute to the association. Additionally, presence of a proinflammatory state shown in recent literature in both diabetes and depression may contribute to this as well. The objectives of this review are to summarize and review the recent evidence showing alterations of these three biological systems-HPA axis, SNS, and inflammatory cascade--in depression, diabetes, and diabetes-related risk factors. |
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Authors:
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Shivam Champaneri; Gary S Wand; Saurabh S Malhotra; Sarah S Casagrande; Sherita Hill Golden |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Current diabetes reports Volume: 10 ISSN: 1539-0829 ISO Abbreviation: Curr. Diab. Rep. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-18 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101093791 Medline TA: Curr Diab Rep Country: United States |
Other Details:
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Languages: eng Pagination: 396-405 Citation Subset: IM |
Affiliation:
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Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Depression / etiology*, metabolism, physiopathology* Diabetes Complications / complications* Diabetes Mellitus / metabolism, physiopathology* Humans Hypothalamo-Hypophyseal System / metabolism, physiopathology Inflammation / metabolism, physiopathology Pituitary-Adrenal System / metabolism, physiopathology Sympathetic Nervous System / metabolism, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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5K23 DK071565/DK/NIDDK NIH HHS; M01-RR00052/RR/NCRR NIH HHS; P60 DK079637/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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