Document Detail

Biologic therapy for psoriasis: the T-cell-targeted therapies efalizumab and alefacept.
MedLine Citation:
PMID:  12553629     Owner:  NLM     Status:  MEDLINE    
During the past several years, a new generation of therapies for psoriasis has been in development. These biologic therapies target the activity of T lymphocytes and cytokines responsible for the inflammatory nature of this disease. The first article of this 2-part update reviewed the tumor necrosis factor (TNF) inhibitors, infliximab and etanercept. In this article, we will review 2 therapies that target the T cell, efalizumab and alefacept.
Jeffrey M Weinberg; William D Tutrone
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cutis     Volume:  71     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-29     Completed Date:  2003-04-18     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-5     Citation Subset:  IM    
Department of Dermatology. St. Luke's-Roosevelt Hospital Center, 1090 Amsterdam Ave, Suite 11D, New York, NY 10025, USA.
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MeSH Terms
Antibodies, Monoclonal / administration & dosage*,  pharmacology,  therapeutic use*
Biological Therapy*
Drug Delivery Systems*
Psoriasis / drug therapy*
Recombinant Fusion Proteins / administration & dosage*,  pharmacology,  therapeutic use*
T-Lymphocytes / drug effects*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Recombinant Fusion Proteins; 0/efalizumab; ELK3V90G6C/alefacept

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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