Document Detail

Biologic and methodologic issues for nutritional biomarkers.
MedLine Citation:
PMID:  12612173     Owner:  NLM     Status:  MEDLINE    
Nutritional biomarkers are used for a variety of purposes in large-scale population surveys and epidemiologic studies as well as smaller clinical studies. The main reasons for using nutritional biomarkers are to provide measures of nutritional status that have less error than dietary data, nutrient status for nutrients with inadequate dietary data, to obtain a more proximal and integrated assessment of nutrient status that incorporates metabolism, to assess dietary change and compliance in intervention studies, and dietary intake for the validation of dietary questionnaires. However, often there is oversight by the investigators regarding biologic and laboratory issues, which have implications for the utility of nutritional biomarkers. This article reviews some of the physiologic issues that contribute to between-person variability in nutrient status and the utility and meaning of specimens from various body compartments. Issues related to the collection and storage of biologic specimens are addressed, although it is recommended that investigators contact laboratory colleagues at the beginning of any study for updated information. The necessity for blind quality surveillance of laboratory analyses beyond the normal procedures employed by collaborating laboratories also is addressed. The advantages and disadvantages of nutritional biomarkers are reviewed, especially in comparison with using dietary methodology.
Nancy Potischman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of nutrition     Volume:  133 Suppl 3     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-03     Completed Date:  2003-04-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  875S-880S     Citation Subset:  IM    
National Cancer Institute, Bethesda, MD 20892, USA.
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MeSH Terms
Biological Markers* / analysis
Blood Chemical Analysis / methods
Hot Temperature
Nutritional Physiological Phenomena
Nutritional Status*
Nutritive Value
Specimen Handling
Time Factors
Tissue Distribution
Reg. No./Substance:
0/Biological Markers

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