| Biologic features and prognosis of ductal carcinoma in situ are not adversely impacted by initial large body mass. | |
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MedLine Citation:
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PMID: 22392043 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Obesity is associated with adverse biologic features and poor outcome in patients with invasive breast cancer, yet this relationship has not been evaluated in patients with ductal carcinoma in situ (DCIS). From 1996 to 2009, body mass index (BMI) was recorded at initial diagnosis for 1,885 patients with DCIS treated at our institution. Patients were categorized as obese (BMI ≥ 30 kg/m(2)), overweight (BMI 25 to <30 kg/m(2)), or of normal weight or underweight (BMI < 25 kg/m(2)). Logistic regression was used to examine associations between BMI and patient, clinical, and pathologic features and treatment. Local-regional recurrence was calculated using the Kaplan-Meier method. All statistical tests were two-sided. Of the 1,885 patients, 514 (27.7%) were obese, 510 (27.5%) were overweight, and 831 (44.8%) were normal/underweight. In multivariate analysis, overweight and obese patients were significantly more likely to be African American (odds ratio [OR], 3.93; 95% confidence interval [CI], 2.66-5.80) or Hispanic (OR, 1.44; CI, 1.02-2.04), be postmenopausal (OR, 1.63; CI, 1.28-2.07), have diabetes (OR, 4.60; CI, 2.60-8.12), have estrogen-receptor-positive DCIS (OR, 1.39; CI, 1.00-192), and present with a radiologic abnormality rather than clinical symptoms (OR, 1.35; CI, 1.01-1.80). At a median follow-up time of 4.96 years (range, 1.0-14.34 years), no significant differences in local recurrence rates were detected based on patients' initial BMI category. Furthermore, there was no significant difference in risk of recurrence between diabetic patients receiving metformin or not. In conclusion, higher BMI is not associated with adverse biologic features or prognosis in patients with DCIS. |
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Authors:
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Henry M Kuerer; Sara A Lari; Banu K Arun; Chung-Yuan Hu; Abenaa Brewster; Elizabeth A Mittendorf; Constance T Albarracin; Gildy V Babiera; Abigail S Caudle; Jamie L Wagner; Jennifer K Litton; Isabelle Bedrosian; Funda Meric-Bernstam; Anthony Lucci; Kelly K Hunt |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-4 |
Journal Detail:
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Title: Breast cancer research and treatment Volume: - ISSN: 1573-7217 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8111104 Medline TA: Breast Cancer Res Treat Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Surgical Oncology, DCIS Discovery Enterprise, Unit 1484, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77230-1402, USA, hkuerer@mdanderson.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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