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Biologic activities of poly (2-azaadenylic acid) and poly (2-azainosinic acid).
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MedLine Citation:
PMID:  73166     Owner:  NLM     Status:  MEDLINE    
Poly (2-azaadenylic acid) [(aza2A)n] and poly(2-azainosinic acid [(aza2I)n], two newly synthesized analogues of (A)n and (I)n, in which CH-2 of the purine ring is replaced by a nitrogen atom, have been evaluated in various biological assay systems. (Aza2A) n formed a complex with (U)n and (br5U)n, and (aza2I)n formed a complex with (C)n and (br5C)n, but these complexes were markedly destabilized relative to the corresponding (A)n or (I)n complexes. The (aza2A)n-and (aza2I)n-derived complexes failed to stimulate the production of interferon in primary rabbit kidney cells and human diploid fibroblasts, under conditions (A)n. (U)n, (I)n. (C)n and (I)n. (br5C)n induced high amounts of interferon. both (aza2A)n and (aza2I)n exerted a marked inhibitory effect on the endogenous RNA directed DNA polymerase (reverse transcriptase) activity associated with murine leukemia virus. They caused a relatively mild inhibition of complement activity in an hemolytic assay system.
E De Clercq; G F Huang; P F Torrence; T Fukui; N Kakiuchi; M Ikehara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nucleic acids research     Volume:  4     ISSN:  0305-1048     ISO Abbreviation:  Nucleic Acids Res.     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1978-01-27     Completed Date:  1978-01-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0411011     Medline TA:  Nucleic Acids Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3643-53     Citation Subset:  IM    
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MeSH Terms
Aza Compounds / pharmacology
Cell Line
Complement System Proteins / analysis
Hemolysis / drug effects
Interferons / biosynthesis
Nucleic Acid Denaturation
Poly A / pharmacology*
Poly I / pharmacology*
Polyribonucleotides / pharmacology*
Reverse Transcriptase Inhibitors
Reg. No./Substance:
0/Aza Compounds; 0/Polyribonucleotides; 0/Reverse Transcriptase Inhibitors; 24937-83-5/Poly A; 25249-22-3/Poly I; 9007-36-7/Complement System Proteins; 9008-11-1/Interferons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Nucleic Acids Res
ISSN: 0305-1048
ISSN: 1362-4962
Article Information
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Print publication date: Month: 10 Year: 1977
Volume: 4 Issue: 10
First Page: 3643 Last Page: 3653
ID: 342679
PubMed Id: 73166

Biologic activities of poly (2-azaadenylic acid) and poly (2-azainosinic acid).
E De Clercq
G F Huang
P F Torrence
T Fukui
N Kakiuchi
M Ikehara

Article Categories:
  • Research Article

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