| Biokinetics of inhaled 244Cm oxide in the rat: effect of heat treatment at 1150 degrees C. | |
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MedLine Citation:
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PMID: 6706592 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study was conducted in rats to determine solubility and subsequent metabolism of an inhaled aerosol of curium treated at high temperatures. Young adult Fischer-344 rats received a single inhalation exposure to one of three monodisperse aerosols of 244Cm2O3 (0.70, 1.3, or 2.6 micron activity median aerodynamic diameter) heat-treated at 1150 degrees C. Animals were maintained individually in metabolism cages for excreta collection and serially sacrificed in groups of two male and two female rats from 2 to 33 days after inhalation exposure. Additionally an injection study with curium citrate was done to define the systemic behavior of Cm in this rat model. The in vivo solubility was inversely related to the aerosol particle size. The relationship of the results of this study to results from other experimental inhalation studies with curium oxide aerosols is discussed, as is the relevance to bioassay interpretation and risk assessment in man. |
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Authors:
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R A Guilmette; G M Kanapilly; D L Lundgren; A F Eidson |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Health physics Volume: 46 ISSN: 0017-9078 ISO Abbreviation: Health Phys Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-05-23 Completed Date: 1984-05-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985093R Medline TA: Health Phys Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 845-58 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerosols Animals Curium / administration & dosage, analysis*, metabolism*, urine Feces / analysis Female Hot Temperature Injections, Intravenous Male Rats Rats, Inbred F344 Time Factors Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 12016-67-0/curium oxide; 7440-51-9/Curium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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