Document Detail

Biointerface properties of core-shell poly (vinyl alcohol)-hyaluronic acid microgels based on chemo-selective chemistry.
MedLine Citation:
PMID:  23082791     Owner:  NLM     Status:  Publisher    
Chemo-selective chemistry is one of the main synthetic strategies for the design of bioactive constructs. In this contribution we report on the fabrication of core-shell microgel particles, obtained by "click chemistry" and "inverse emulsion droplets" technique. Azido and alkyne derivatives of poly (vinyl alcohol) (PVA) in a 1:2 mole ratio of functional groups, respectively, were crosslinked by click chemistry method. The microgel particles were spherical in shape with an average diameter of about 2 μm and with a narrow size distribution. Residual unreacted alkyne groups present on the particle surface were "clicked" with an azido-grafted hyaluronic acid. These microgel particles with a PVA core and a hyaluronic acid shell were tested for bio-orthogonality, i.e. for the absence of cytotoxicity in the presence of unreacted clickable functionalities, and demonstrated a remarkable ability to target adenocarcinoma colon cells (HT-29) as well as to release locally the anti-tumour drug, doxorubicin. Internalization process was studied in connection with the presence of hyaluronic acid on the microgel particles surface. In this paper we introduce a concept device based on chemo-selective chemistry, which may contributes to the design of micro and nano platforms having controlled and multi-functional structures.
Sidhendra G Kupal; Barbara Cerroni; Shivkumar V Ghugare; Ester Chiessi; Gaio Paradossi
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-19
Journal Detail:
Title:  Biomacromolecules     Volume:  -     ISSN:  1526-4602     ISO Abbreviation:  Biomacromolecules     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892849     Medline TA:  Biomacromolecules     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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