| Bioinformatics challenges for personalized medicine. | |
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MedLine Citation:
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PMID: 21596790 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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MOTIVATION: Widespread availability of low-cost, full genome sequencing will introduce new challenges for bioinformatics. RESULTS: This review outlines recent developments in sequencing technologies and genome analysis methods for application in personalized medicine. New methods are needed in four areas to realize the potential of personalized medicine: (i) processing large-scale robust genomic data; (ii) interpreting the functional effect and the impact of genomic variation; (iii) integrating systems data to relate complex genetic interactions with phenotypes; and (iv) translating these discoveries into medical practice. CONTACT: russ.altman@stanford.edu |
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Authors:
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Guy Haskin Fernald; Emidio Capriotti; Roxana Daneshjou; Konrad J Karczewski; Russ B Altman |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-05-19 |
Journal Detail:
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Title: Bioinformatics (Oxford, England) Volume: 27 ISSN: 1367-4811 ISO Abbreviation: Bioinformatics Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-20 Completed Date: 2011-10-27 Revised Date: 2011-11-23 |
Medline Journal Info:
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Nlm Unique ID: 9808944 Medline TA: Bioinformatics Country: England |
Other Details:
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Languages: eng Pagination: 1741-8 Citation Subset: IM |
Affiliation:
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Biomedical Informatics Training Program, Stanford University School of Medicine, Department of Bioengineering, Stanford University, Stanford, CA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Computational Biology
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methods* Genome-Wide Association Study Human Genome Project* Humans Individualized Medicine* Polymorphism, Single Nucleotide |
| Grant Support | |
ID/Acronym/Agency:
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LM007033/LM/NLM NIH HHS; LM05652/LM/NLM NIH HHS; U01GM61374/GM/NIGMS NIH HHS |
| Comments/Corrections | |
Erratum In:
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Bioinformatics. 2011 Aug 15;27(16):2323 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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