Document Detail

Bioinformatics and the allergy assessment of agricultural biotechnology products: industry practices and recommendations.
MedLine Citation:
PMID:  21320564     Owner:  NLM     Status:  MEDLINE    
Bioinformatic tools are being increasingly utilized to evaluate the degree of similarity between a novel protein and known allergens within the context of a larger allergy safety assessment process. Importantly, bioinformatics is not a predictive analysis that can determine if a novel protein will ''become" an allergen, but rather a tool to assess whether the protein is a known allergen or is potentially cross-reactive with an existing allergen. Bioinformatic tools are key components of the 2009 CodexAlimentarius Commission's weight-of-evidence approach, which encompasses a variety of experimental approaches for an overall assessment of the allergenic potential of a novel protein. Bioinformatic search comparisons between novel protein sequences, as well as potential novel fusion sequences derived from the genome and transgene, and known allergens are required by all regulatory agencies that assess the safety of genetically modified (GM) products. The objective of this paper is to identify opportunities for consensus in the methods of applying bioinformatics and to outline differences that impact a consistent and reliable allergy safety assessment. The bioinformatic comparison process has some critical features, which are outlined in this paper. One of them is a curated, publicly available and well-managed database with known allergenic sequences. In this paper, the best practices, scientific value, and food safety implications of bioinformatic analyses, as they are applied to GM food crops are discussed. Recommendations for conducting bioinformatic analysis on novel food proteins for potential cross-reactivity to known allergens are also put forth.
Gregory S Ladics; Robert F Cressman; Corinne Herouet-Guicheney; Rod A Herman; Laura Privalle; Ping Song; Jason M Ward; Scott McClain
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Publication Detail:
Type:  Journal Article     Date:  2011-02-12
Journal Detail:
Title:  Regulatory toxicology and pharmacology : RTP     Volume:  60     ISSN:  1096-0295     ISO Abbreviation:  Regul. Toxicol. Pharmacol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-23     Completed Date:  2011-09-06     Revised Date:  2012-08-08    
Medline Journal Info:
Nlm Unique ID:  8214983     Medline TA:  Regul Toxicol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  46-53     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Pioneer Hi-Bred International Inc., DuPont Agricultural Biotechnology, P.O. Box 80353, Wilmington, DE 19880, USA.
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MeSH Terms
Allergens / adverse effects*,  chemistry,  classification
Amino Acid Sequence
Biotechnology / methods*
Computational Biology
Consumer Product Safety
Databases, Protein
Dietary Proteins / analysis,  immunology*
Food, Genetically Modified / adverse effects*,  classification
Health Planning Guidelines
Molecular Sequence Data
Plant Proteins / analysis,  immunology*
Plants, Genetically Modified
Reg. No./Substance:
0/Allergens; 0/Dietary Proteins; 0/Plant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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