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Bioinformatic investigation of the cost management strategies of five oral microbes.
MedLine Citation:
PMID:  25052707     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Some amino acids are more energetically costly to synthesise de novo, therefore many microbes have evolved to regulate the metabolic expenditure of the cell and reduce the energy burden of extracellular unrecyclable proteins. Several oral bacterial species take up amino acids and peptides obtained from proteolysis of host proteins and hence do not rely only on de novo synthesis. The aim of this study was to investigate if five oral bacterial species implement cost management strategies to reduce the energy burden of extracellular unrecyclable proteins. Since the relative de novo amino acid synthetic costs are proportional to the masses of the amino acids, the energy costs of producing proteins were assessed by calculating the mean amino acid mass for each protein. For Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Prevotella intermedia, and Streptococcus sanguinis, the outer membrane/extracellular proteins are made up of a much larger percentage of lower average mass amino acids whereas cytoplasmic proteins are made up of a larger proportion of higher average mass amino acid residues. These results are consistent with the five oral bacterial species employing energy-saving mechanisms in the production of extracellular unrecyclable proteins. Interestingly, the P. gingivalis and S. sanguinis genomes exhibited significantly lower predicted mean amino acid masses compared with that of the genomes of the other three species suggesting this may provide them with an energy advantage with respect to protein biosynthetic cost. This article is protected by copyright. All rights reserved.
Authors:
Keith J Cross; N Laila Huq; Seung Hyun Park; Jun Sung Park; Pauline Pham; Minn Quah; Mathuri Ranjan; Eric C Reynolds
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-22
Journal Detail:
Title:  Molecular oral microbiology     Volume:  -     ISSN:  2041-1014     ISO Abbreviation:  Mol Oral Microbiol     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101524770     Medline TA:  Mol Oral Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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