| Bioguided isolation of pentacyclic triterpenes from the leaves of Alstonia scholaris (Linn.) R. Br. growing in Egypt. | |
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MedLine Citation:
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PMID: 21919561 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Ethanolic and aqueous extracts of the leaves and flowers of Alstonia scholaris were evaluated for their antioxidant activity by investigating their effect on blood glutathione levels in alloxan-induced diabetic rats. The ethanolic extract of the leaves was the most active; therefore, its cytotoxicity against HepG2 cells was also tested. Promising GI(50) values of 1.96, 4.34 and 4.65??g?mL(?1) were observed for the extract, its chloroform and ethyl acetate fractions, respectively. The chloroform active subfraction I (GI(50)?=?2.97??g?mL(?1)) yielded betulin (1), betulinic acid (2) and ursolic acid (3) upon purification. Compounds 1?3 were identified using spectroscopic techniques and by comparison with reported data. GLC of unsaponifiable and saponifiable fractions of the hexane extract revealed ?-sitosterol (7.37%) and n-tetracosane (54.4%) to be the major sterol and hydrocarbon components, respectively. Linoleic acid (48.89%) was the predominant fatty acid. |
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Authors:
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Hesham I El-Askary; Mahmoud M El-Olemy; Maha M Salama; Amany A Sleem; Mahetab H Amer |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-15 |
Journal Detail:
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Title: Natural product research Volume: - ISSN: 1478-6427 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101167924 Medline TA: Nat Prod Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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a Department of Pharmacognosy, Faculty of Pharmacy , Cairo University , Cairo 11562 , Egypt. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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